caa a22 4500 606156658 CHVBK 20210128100609.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10096-015-2446-2 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2446-2 Factors predicting kidney damage in Puumala virus infected patients in Southern Denmark [Elektronische Daten] [S. Skarphedinsson, H. Thiesson, S. Shakar, M. Tepel] In Europe, infections with Puumala hantavirus cause nephropathia epidemica. Presently the risk factors predicting severe kidney damage after Puumala virus infection are not well known. The objective of the study was to investigate environmental and individual factors predicting severe kidney damage caused by serologically established Puumala infections. In a nationwide cohort study we investigated all serologically established Puumala infections in Southern Denmark from 1996 to 2012. A total of 184 patients had serologically verified Puumala virus infection. In patients with Puumala virus infections the decrease of platelet counts preceded acute kidney failure. Multivariable logistic regression demonstrated that recent activities in the forest, platelet counts, and flu-like symptoms predicted estimated glomerular filtration rates less than 30mL/min/1.73m², but not age, gender, fever, nor abdominal pain. Severe kidney damage in Puumala infections in Southern Denmark is associated with the risk of recent activities in the forest. Springer-Verlag Berlin Heidelberg, 2015 Skarphedinsson S. Clinical Center of Emerging and Vectorborne Infections, Department of Infectious Diseases, Odense University Hospital, Odense, Denmark aut Thiesson H. Department of Nephrology, Odense University Hospital, Odense, Denmark aut Shakar S. Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark aut Tepel M. Department of Nephrology, Odense University Hospital, Odense, Denmark aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/10(2015-10-01), 2017-2021 0934-9723 34:10<2017 2015 34 10096 https://doi.org/10.1007/s10096-015-2446-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2446-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Skarphedinsson S. Clinical Center of Emerging and Vectorborne Infections, Department of Infectious Diseases, Odense University Hospital, Odense, Denmark aut NATIONALLICENCE 700 1- Thiesson H. Department of Nephrology, Odense University Hospital, Odense, Denmark aut NATIONALLICENCE 700 1- Shakar S. Department of Infectious Diseases, Aalborg University Hospital, Aalborg, Denmark aut NATIONALLICENCE 700 1- Tepel M. Department of Nephrology, Odense University Hospital, Odense, Denmark aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/10(2015-10-01), 2017-2021 0934-9723 34:10<2017 2015 34 10096