caa a22 4500 606156674 CHVBK 20210128100609.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10096-015-2462-2 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2462-2 Epidemiology and emm types of invasive group A streptococcal infections in Finland, 2008-2013 [Elektronische Daten] [P. Smit, L. Lindholm, O. Lyytikäinen, J. Jalava, A. Pätäri-Sampo, J. Vuopio] Invasive Streptococcus pyogenes (group A streptococcus, GAS) infections are a major global cause of morbidity and mortality. We analysed the surveillance data on invasive GAS and the microbiological characteristics of corresponding isolates to assess the incidence and emm type distribution of invasive GAS infections in Finland. Cases defined as patients with isolations of blood and cerebrospinal fluid S. pyogenes are mandatorily notified to the National Infectious Disease Registry and sent to the national reference laboratory for emm typing. Antimicrobial data were collected through the network including all clinical microbiology laboratories. Pulsed-field gel electrophoresis (PFGE) analysis was performed to assess clonality. In total, 1165 cases of invasive GAS were reported in Finland during 2008-2013; the median age was 52years (range, 0-100) and 54% were male. The overall day 7 case fatality rate was 5.1% (59 cases). The average annual incidence was 3.6 cases per 100,000 population. A total of 1122 invasive GAS isolates (96%) were analysed by emm typing; 72 different emm types were identified, of which emm28 (297 isolates, 26%), emm89 (193 isolates, 12%) and emm1 (132 isolates, 12%) were the most common types. During 2008-2013, an increase of erythromycin resistance (1.9% to 8.7%) and clindamycin (0.9% to 9.2%) was observed. This resistance increase was in parallel with the introduction of a novel clone emm33 into Finland. The overall incidence of invasive GAS infections remained stable over the study period in Finland. We identified clonal spread of macrolide-resistant invasive emm33 GAS type, highlighting the importance of molecular surveillance. Springer-Verlag Berlin Heidelberg, 2015 Smit P. European Public Health Microbiology Training Programme (EUPHEM), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden aut Lindholm L. Department of Infections, Bacterial Infections Unit, National Institute for Health and Welfare, Turku, Finland aut Lyytikäinen O. Department of Infections, Infectious Disease Control Unit, National Institute for Health and Welfare, Helsinki, Finland aut Jalava J. Department of Infections, Bacterial Infections Unit, National Institute for Health and Welfare, Turku, Finland aut Pätäri-Sampo A. Division of Clinical Microbiology, HUSLAB, Helsinki University Hospital, Helsinki, Finland aut Vuopio J. Department of Infections, Bacterial Infections Unit, National Institute for Health and Welfare, Turku, Finland aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/10(2015-10-01), 2131-2136 0934-9723 34:10<2131 2015 34 10096 https://doi.org/10.1007/s10096-015-2462-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2462-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Smit P. European Public Health Microbiology Training Programme (EUPHEM), European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden aut NATIONALLICENCE 700 1- Lindholm L. Department of Infections, Bacterial Infections Unit, National Institute for Health and Welfare, Turku, Finland aut NATIONALLICENCE 700 1- Lyytikäinen O. Department of Infections, Infectious Disease Control Unit, National Institute for Health and Welfare, Helsinki, Finland aut NATIONALLICENCE 700 1- Jalava J. Department of Infections, Bacterial Infections Unit, National Institute for Health and Welfare, Turku, Finland aut NATIONALLICENCE 700 1- Pätäri-Sampo A. Division of Clinical Microbiology, HUSLAB, Helsinki University Hospital, Helsinki, Finland aut NATIONALLICENCE 700 1- Vuopio J. Department of Infections, Bacterial Infections Unit, National Institute for Health and Welfare, Turku, Finland aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/10(2015-10-01), 2131-2136 0934-9723 34:10<2131 2015 34 10096