caa a22 4500 606156739 CHVBK 20210128100610.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10096-015-2455-1 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2455-1 Dramatic decrease of Streptococcus pneumoniae infections in Marseille, 2003-2014 [Elektronische Daten] [C. Abat, D. Raoult, J.-M. Rolain] We studied the evolution of the prevalence of pneumococcal infections in university hospitals in Marseille, France, from January 2003 to December 2014, and compared our observations and results to available international data. We collected data referring to patients hospitalised for Streptococcus pneumoniae infections in the four university hospitals of Marseille from January 2003 to December 2014. We then calculated percentages of positiveness to pneumococcal strains by dividing the annual number of patients infected by pneumococcal strains by the annual number of patients found to be infected by at least one bacterial species in the settings of interest throughout the study period. Overall, 2442 non-redundant patients were infected by S. pneumoniae strains throughout the study period. We observed that the annual percentage of patients infected by S. pneumoniae significantly decreased throughout the study period (from 1.99% in 2003 to 0.77% in 2014, p-value < 10−4). A significant correlation was obtained comparing the annual evolution of the percentage of patients positive to pneumococcal strains aged under 21years to that of patients aged over 21 years (r = 0.93, p-value < 10−5). Our results allowed us to prove that national immunisation programmes effectively impact on the pneumococcal infection prevalence in young and elderly populations, even on the regional scale. Springer-Verlag Berlin Heidelberg, 2015 Abat C. URMITE UM 63 CNRS 7278 IRD 198 INSERM U1905, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille Université, 27 boulevard Jean Moulin, 13385, Marseille CEDEX 05, France aut Raoult D. URMITE UM 63 CNRS 7278 IRD 198 INSERM U1905, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille Université, 27 boulevard Jean Moulin, 13385, Marseille CEDEX 05, France aut Rolain J.-M URMITE UM 63 CNRS 7278 IRD 198 INSERM U1905, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille Université, 27 boulevard Jean Moulin, 13385, Marseille CEDEX 05, France aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/10(2015-10-01), 2081-2087 0934-9723 34:10<2081 2015 34 10096 https://doi.org/10.1007/s10096-015-2455-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2455-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abat C. URMITE UM 63 CNRS 7278 IRD 198 INSERM U1905, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille Université, 27 boulevard Jean Moulin, 13385, Marseille CEDEX 05, France aut NATIONALLICENCE 700 1- Raoult D. URMITE UM 63 CNRS 7278 IRD 198 INSERM U1905, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille Université, 27 boulevard Jean Moulin, 13385, Marseille CEDEX 05, France aut NATIONALLICENCE 700 1- Rolain J.-M URMITE UM 63 CNRS 7278 IRD 198 INSERM U1905, IHU Méditerranée Infection, Faculté de Médecine et de Pharmacie, Aix-Marseille Université, 27 boulevard Jean Moulin, 13385, Marseille CEDEX 05, France aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/10(2015-10-01), 2081-2087 0934-9723 34:10<2081 2015 34 10096