caa a22 4500 606156755 CHVBK 20210128100610.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10096-015-2452-4 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2452-4 Risk factors for and impact of carbapenem-resistant Acinetobacter baumannii colonization and infection: matched case-control study [Elektronische Daten] [O. Henig, G. Weber, M. Hoshen, M. Paul, L. German, A. Neuberger, I. Gluzman, A. Berlin, C. Shapira, R. Balicer] The objective of this investigation was to identify risk factors for carbapenem-resistant Acinetobacter baumannii (CRAB) and its association with mortality. A population-based matched case-control study using the computerized database of Clalit Health Services (CHS) in the period between 2007 and 2012 was conducted. Hospitalized patients with CRAB colonization or infection were compared to hospitalized patients without evidence of A. baumannii, matched by age, ward of hospitalization, season, Charlson score, and length of hospitalization. Risk factors for CRAB isolation were searched for using multivariate analysis. Association of CRAB and other risk factors with mortality were assessed in the cohort. A total of 1190 patients with CRAB were matched to 1190 patients without CRAB. Low socioeconomic status was independently associated with CRAB isolation and CRAB bacteremia [odds ratio 2.18, 95% confidence interval (CI) 1.02-5]. Other risk factors were invasive procedures and bacteremia with other pathogens prior to CRAB isolation, and various comorbidities. Among all patients, CRAB isolation was independently associated with increased mortality (hazard ratio 2.33, 95% CI 2.08-2.6). Socioeconomic status is associated with health outcomes. Our population-based study revealed an almost doubled risk for CRAB in patients at lower socioeconomic status and an association with healthcare exposure. CRAB was associated with mortality and might become a risk indicator for complex morbidity and mortality. Springer-Verlag Berlin Heidelberg, 2015 Henig O. Infectious Disease Unit, Lady Davis Carmel Medical Center, 7 Michal Street, Haifa, Israel aut Weber G. Infectious Disease Unit, Lady Davis Carmel Medical Center, 7 Michal Street, Haifa, Israel aut Hoshen M. Clalit Research Institute, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel aut Paul M. Division of Infectious Diseases, Rambam Health Care Campus, Haifa, Israel aut German L. Clalit Research Institute, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel aut Neuberger A. Division of Infectious Diseases, Rambam Health Care Campus, Haifa, Israel aut Gluzman I. Clalit Research Institute, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel aut Berlin A. Clalit Research Institute, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel aut Shapira C. Technion Faculty of Medicine, Haifa, Israel aut Balicer R. Clalit Research Institute, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/10(2015-10-01), 2063-2068 0934-9723 34:10<2063 2015 34 10096 https://doi.org/10.1007/s10096-015-2452-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2452-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Henig O. Infectious Disease Unit, Lady Davis Carmel Medical Center, 7 Michal Street, Haifa, Israel aut NATIONALLICENCE 700 1- Weber G. Infectious Disease Unit, Lady Davis Carmel Medical Center, 7 Michal Street, Haifa, Israel aut NATIONALLICENCE 700 1- Hoshen M. Clalit Research Institute, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Paul M. Division of Infectious Diseases, Rambam Health Care Campus, Haifa, Israel aut NATIONALLICENCE 700 1- German L. Clalit Research Institute, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Neuberger A. Division of Infectious Diseases, Rambam Health Care Campus, Haifa, Israel aut NATIONALLICENCE 700 1- Gluzman I. Clalit Research Institute, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Berlin A. Clalit Research Institute, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Shapira C. Technion Faculty of Medicine, Haifa, Israel aut NATIONALLICENCE 700 1- Balicer R. Clalit Research Institute, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/10(2015-10-01), 2063-2068 0934-9723 34:10<2063 2015 34 10096