caa a22 4500 606156909 CHVBK 20210128100611.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10096-015-2459-x doi (NATIONALLICENCE)springer-10.1007/s10096-015-2459-x Clinical and antimicrobial efficacy of a controlled-release device containing chlorhexidine in the treatment of chronic periodontitis [Elektronische Daten] [S. Pattnaik, N. Anand, S. Chandrasekaran, L. Chandrashekar, K. Mahalakshmi, A. Satpathy] A controlled-release device (CRD) containing chlorhexidine gluconate, such as PerioCol™CG (Eucare Pharmaceuticals Pvt. Ltd,, Chennai, India), for subgingival application has little reported data with clinical as well as antimicrobial efficacy. This study evaluated clinical and subgingival microbial changes on using indigenously developed PerioCol™CG as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis. Forty posterior first molar sites having probing pocket depth ≥5mm were selected and divided into two groups, with 20 sites in each group, in a split-mouth design. Group A (test site) was treated with SRP and PerioCol™CG, while group B (control site) was treated with SRP alone. Subgingival microbial samples were collected at baseline and 1month after the initial SRP, while probing depth (PD), clinical attachment level (CAL) and gingival index (GI) were recorded at baseline, after 1month and after 3months. Microbial detection of Porphyromonas gingivalis (P. gingivalis) and Tannerella forsythia (T. forsythia) was done by means of polymerase chain reaction (PCR). A significant improvement was observed in all clinical measures in sites treated with PerioCol™CG as compared to the control sites during the study period. Also, there was a statistically significant reduction in the proportion of occurrence of P. gingivalis and T. forsythia after intervention in test sites as compared to control sites. Our data suggest that SRP combined with subgingival administration of PerioCol™CG has a significantly better and prolonged effect compared to SRP alone on the PD, clinical attachment loss and elimination of periodontopathogens. Springer-Verlag Berlin Heidelberg, 2015 Pattnaik S. Department of Periodontics, Hi-Tech Dental College and Hospital, 751025, Bhubaneswar, Odisha, India aut Anand N. Department of Periodontics, Sree Balaji Dental College and Hospital, 600100, Chennai, Tamil Nadu, India aut Chandrasekaran S. Department of Periodontics, Sree Balaji Dental College and Hospital, 600100, Chennai, Tamil Nadu, India aut Chandrashekar L. Department of Periodontics, Hi-Tech Dental College and Hospital, 751025, Bhubaneswar, Odisha, India aut Mahalakshmi K. Department of Microbiology, Sree Balaji Dental College and Hospital, 600100, Chennai, Tamil Nadu, India aut Satpathy A. Department of Periodontics and Oral Implantology, Institute of Dental Sciences, Siksha ‘O' Anusandhan University, Khandagiri Square, 751003, Bhubaneswar, Odisha, India aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/10(2015-10-01), 2103-2110 0934-9723 34:10<2103 2015 34 10096 https://doi.org/10.1007/s10096-015-2459-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2459-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pattnaik S. Department of Periodontics, Hi-Tech Dental College and Hospital, 751025, Bhubaneswar, Odisha, India aut NATIONALLICENCE 700 1- Anand N. Department of Periodontics, Sree Balaji Dental College and Hospital, 600100, Chennai, Tamil Nadu, India aut NATIONALLICENCE 700 1- Chandrasekaran S. Department of Periodontics, Sree Balaji Dental College and Hospital, 600100, Chennai, Tamil Nadu, India aut NATIONALLICENCE 700 1- Chandrashekar L. Department of Periodontics, Hi-Tech Dental College and Hospital, 751025, Bhubaneswar, Odisha, India aut NATIONALLICENCE 700 1- Mahalakshmi K. Department of Microbiology, Sree Balaji Dental College and Hospital, 600100, Chennai, Tamil Nadu, India aut NATIONALLICENCE 700 1- Satpathy A. Department of Periodontics and Oral Implantology, Institute of Dental Sciences, Siksha ‘O' Anusandhan University, Khandagiri Square, 751003, Bhubaneswar, Odisha, India aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/10(2015-10-01), 2103-2110 0934-9723 34:10<2103 2015 34 10096