caa a22 4500 606156917 CHVBK 20210128100611.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10096-015-2457-z doi (NATIONALLICENCE)springer-10.1007/s10096-015-2457-z Clinical characteristics of 154 patients suspected of having Ebola virus disease in the Ebola holding center of Jui Government Hospital in Sierra Leone during the 2014 Ebola outbreak [Elektronische Daten] [T. Yan, J. Mu, E. Qin, Y. Wang, L. Liu, D. Wu, H. Jia, Z. Li, T. Guo, X. Wang, Y. Qin, Y. Li, S. Chen, Y. Zhang, J. Zhang, Y. Wu, S. Wang, J. Li] This article sought to analyze the clinical features of 154 patients suspected of having Ebola virus disease (EVD) in an Ebola holding center in Sierra Leone from October 1 through November 9, 2014. We found that 108 of the 154 patients were confirmed with EVD. Eighty-five had known outcomes. Forty-nine of the 85 patients had been exposed to EVD. The average mortality rate was 60%. The mean interval between the onset of symptoms and hospitalization was 5.8 ± 3.3days. The mean incubation period was 9.2 ± 6.7days. Common symptoms of the EVD patients on admission were fatigue (85.2%), anorexia (84.3%), fever (75.9%), and headache (72.2%). Our data showed that the total symptoms of confirmed EVD patients were significantly higher than those of non-EVD patients (9 vs. 5.5; p < 0.001). The likelihood of EVD was 87.6% when a patient presented more than 6 out of 21 symptoms on admission. The survivors were significantly younger than non-survivors (24.0 ± 10.0years vs. 31.3 ± 15.3years; p = 0.016). The real-time polymerase chain reaction (PCR) analysis showed that, in the survivors, the virus load was significantly lower (Ct value: 25.2 ± 4.1 vs. 28.7 ± 5.7; p = 0.002). Multivariate analysis showed that age, fever, and viral load were independent predictors of mortality. Taken together, our data suggested that a cutoff of six symptoms could be used to predict patients with high or low risk of EVD. It seemed that age, fever, and viral load were the main risk factors associated with EVD mortality. Springer-Verlag Berlin Heidelberg, 2015 Yan T. International Liver Disease Diagnosis and Treatment Center, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut Mu J. Intensive Care Center, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut Qin E. Infectious Disease Treatment and Research Center, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut Wang Y. Outpatient Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut Liu L. Radiotherapy Center, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut Wu D. Infectious Disease Treatment and Research Center, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut Jia H. Hospital Infection Control Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut Li Z. Liver and Gall Surgical Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut Guo T. Clinical Laboratory Center, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut Wang X. Obstetrics and Gynecology Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut Qin Y. Outpatient Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut Li Y. Nursing Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut Chen S. Intensive Care Center, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut Zhang Y. Nursing Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut Zhang J. Nursing Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut Wu Y. Liver and Gall Surgical Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut Wang S. Information Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut Li J. Administration Office, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/10(2015-10-01), 2089-2095 0934-9723 34:10<2089 2015 34 10096 https://doi.org/10.1007/s10096-015-2457-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2457-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yan T. International Liver Disease Diagnosis and Treatment Center, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut NATIONALLICENCE 700 1- Mu J. Intensive Care Center, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut NATIONALLICENCE 700 1- Qin E. Infectious Disease Treatment and Research Center, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut NATIONALLICENCE 700 1- Wang Y. Outpatient Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut NATIONALLICENCE 700 1- Liu L. Radiotherapy Center, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut NATIONALLICENCE 700 1- Wu D. Infectious Disease Treatment and Research Center, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut NATIONALLICENCE 700 1- Jia H. Hospital Infection Control Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut NATIONALLICENCE 700 1- Li Z. Liver and Gall Surgical Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut NATIONALLICENCE 700 1- Guo T. Clinical Laboratory Center, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut NATIONALLICENCE 700 1- Wang X. Obstetrics and Gynecology Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut NATIONALLICENCE 700 1- Qin Y. Outpatient Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut NATIONALLICENCE 700 1- Li Y. Nursing Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut NATIONALLICENCE 700 1- Chen S. Intensive Care Center, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut NATIONALLICENCE 700 1- Zhang Y. Nursing Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut NATIONALLICENCE 700 1- Zhang J. Nursing Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut NATIONALLICENCE 700 1- Wu Y. Liver and Gall Surgical Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut NATIONALLICENCE 700 1- Wang S. Information Department, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut NATIONALLICENCE 700 1- Li J. Administration Office, 302 Military Hospital, 100 West 4th Ring Middle Road, 100039, Beijing, China aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/10(2015-10-01), 2089-2095 0934-9723 34:10<2089 2015 34 10096