caa a22 4500 606156984 CHVBK 20210128100611.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10096-014-2293-6 doi (NATIONALLICENCE)springer-10.1007/s10096-014-2293-6 Trends and correlation of antibacterial usage and bacterial resistance: time series analysis for antibacterial stewardship in a Chinese teaching hospital (2009-2013) [Elektronische Daten] [Y. Zou, Y. Ma, J. Liu, J. Shi, T. Fan, Y. Shan, H. Yao, Y. Dong] The purpose of this investigation was to describe the effect of antibacterial stewardship and evaluate the trends and correlation of antibacterial resistance and usage from 2009 to 2013 in a tertiary-care teaching hospital in northwest China. Antibacterial usage was expressed as defined daily doses per 100 patients per day (DDDs/100 PDs). Hospital-wide population-level data and time series analysis were used to evaluate the trends and determine associations between antibacterial exposure and acquisition of resistance. Yearly consumption of overall antibacterials significantly decreased from 66.54 to 28.08 DDDs/100 PDs (β = −10.504, p < 0.01). The resistant rates of the five most frequently isolated species (including Escherichia coli, Acinetobacter baumannii, Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae) significantly decreased or remained stable, and none of them showed a statistically significant upward trend. The medical quality indicators got better or remained stable. Autoregressive integrated moving average (ARIMA) models demonstrated that the monthly resistance rate of P. aeruginosa to imipenem was strongly correlated with antipseudomonal carbapenems usage (β = 34.94, p < 0.001), as did the correlation of P. aeruginosa to meropenem with antipseudomonal third-generation cephalosporins usage (β = 32.76, p < 0.01) and K. pneumoniae to amikacin with aminoglycosides usage (β = 22.01, p < 0.001). The decreased antibacterial use paralleled the improved bacterial resistance without deteriorating medical quality indicators during antimicrobial stewardship. It also suggests that optimum antibiotic use is necessary to alleviate the threat posed by resistant microorganisms at the hospital level. Springer-Verlag Berlin Heidelberg, 2014 Zou Y. Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, 710061, Xi'an, China aut Ma Y. Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, 710061, Xi'an, China aut Liu J. Department of Clinical Laboratory, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China aut Shi J. Medical Department, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China aut Fan T. Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, 710061, Xi'an, China aut Shan Y. Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, 710061, Xi'an, China aut Yao H. Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, 710061, Xi'an, China aut Dong Y. Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, 710061, Xi'an, China aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/4(2015-04-01), 795-803 0934-9723 34:4<795 2015 34 10096 https://doi.org/10.1007/s10096-014-2293-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-014-2293-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zou Y. Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 700 1- Ma Y. Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 700 1- Liu J. Department of Clinical Laboratory, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China aut NATIONALLICENCE 700 1- Shi J. Medical Department, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China aut NATIONALLICENCE 700 1- Fan T. Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 700 1- Shan Y. Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 700 1- Yao H. Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 700 1- Dong Y. Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, 710061, Xi'an, China aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/4(2015-04-01), 795-803 0934-9723 34:4<795 2015 34 10096