caa a22 4500 606157050 CHVBK 20210128100611.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10096-014-2274-9 doi (NATIONALLICENCE)springer-10.1007/s10096-014-2274-9 Evidence of streptococcal origin of acute non-necrotising cellulitis: a serological study [Elektronische Daten] [M. Karppelin, T. Siljander, A.-M. Haapala, J. Aittoniemi, R. Huttunen, J. Kere, J. Vuopio, J. Syrjänen] Bacteriological diagnosis is rarely achieved in acute cellulitis. Beta-haemolytic streptococci and Staphylococcus aureus are considered the main pathogens. The role of the latter is, however, unclear in cases of non-suppurative cellulitis. We conducted a serological study to investigate the bacterial aetiology of acute non-necrotising cellulitis. Anti-streptolysin O (ASO), anti-deoxyribonuclease B (ADN) and anti-staphylolysin (ASTA) titres were measured from acute and convalescent phase sera of 77 patients hospitalised because of acute bacterial non-necrotising cellulitis and from the serum samples of 89 control subjects matched for age and sex. Antibiotic treatment decisions were also reviewed. Streptococcal serology was positive in 53 (69%) of the 77 cases. Furthermore, ten cases without serological evidence of streptococcal infection were successfully treated with penicillin. Positive ASO and ADN titres were detected in ten (11%) and three (3%) of the 89 controls, respectively, and ASTA was elevated in three patients and 11 controls. Our findings suggest that acute non-necrotising cellulitis without pus formation is mostly of streptococcal origin and that penicillin can be used as the first-line therapy for most patients. Springer-Verlag Berlin Heidelberg, 2014 Karppelin M. Department of Internal Medicine, Tampere University Hospital, P.O. Box 2000, 33521, Tampere, Finland aut Siljander T. Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki and Turku, Finland aut Haapala A.-M Department of Clinical Microbiology, Fimlab Laboratories, Tampere, Finland aut Aittoniemi J. Department of Clinical Microbiology, Fimlab Laboratories, Tampere, Finland aut Huttunen R. Department of Internal Medicine, Tampere University Hospital, P.O. Box 2000, 33521, Tampere, Finland aut Kere J. Molecular Neurology Research Program, University of Helsinki and Folkhälsan Institute of Genetics, Helsinki, Finland aut Vuopio J. Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki and Turku, Finland aut Syrjänen J. Department of Internal Medicine, Tampere University Hospital, P.O. Box 2000, 33521, Tampere, Finland aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/4(2015-04-01), 669-672 0934-9723 34:4<669 2015 34 10096 https://doi.org/10.1007/s10096-014-2274-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-014-2274-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Karppelin M. Department of Internal Medicine, Tampere University Hospital, P.O. Box 2000, 33521, Tampere, Finland aut NATIONALLICENCE 700 1- Siljander T. Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki and Turku, Finland aut NATIONALLICENCE 700 1- Haapala A.-M Department of Clinical Microbiology, Fimlab Laboratories, Tampere, Finland aut NATIONALLICENCE 700 1- Aittoniemi J. Department of Clinical Microbiology, Fimlab Laboratories, Tampere, Finland aut NATIONALLICENCE 700 1- Huttunen R. Department of Internal Medicine, Tampere University Hospital, P.O. Box 2000, 33521, Tampere, Finland aut NATIONALLICENCE 700 1- Kere J. Molecular Neurology Research Program, University of Helsinki and Folkhälsan Institute of Genetics, Helsinki, Finland aut NATIONALLICENCE 700 1- Vuopio J. Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Helsinki and Turku, Finland aut NATIONALLICENCE 700 1- Syrjänen J. Department of Internal Medicine, Tampere University Hospital, P.O. Box 2000, 33521, Tampere, Finland aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/4(2015-04-01), 669-672 0934-9723 34:4<669 2015 34 10096