caa a22 4500 606157093 CHVBK 20210128100611.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10096-014-2283-8 doi (NATIONALLICENCE)springer-10.1007/s10096-014-2283-8 Recent trends in epidemiology of invasive pneumococcal disease in Poland [Elektronische Daten] [A. Skoczyńska, A. Kuch, E. Sadowy, I. Waśko, M. Markowska, P. Ronkiewicz, B. Matynia, A. Bojarska, K. Wasiak, A. Gołębiewska, M. van der Linden, W. Hryniewicz] The objectives of this study were to assess the current incidence of invasive pneumococcal disease (IPD) in Poland (2011-2013), where mass vaccination has not been implemented, and to characterize the Streptococcus pneumoniae isolates responsible for invasive infections by determining their serotype distribution and antimicrobial resistance patterns. For all isolates identification, serotyping and antimicrobial minimal inhibitory concentrations determination were performed based on routine techniques. The highest incidence rates were observed among adults older than 85years old (4.62/100,000) and children under 1year of age (4.28/100,000). The general case fatality ratio (CFR) was 25.4%, with the highest CFR in the age group ≥85years old (59.7%). The most common serotypes were 3, 14, 19A, 4, 9V, 19F, 1, and 23F (61.3% of all isolates). The 10- and 13-valent pneumococcal conjugated vaccines (PCV) covered 46.0 and 71.8% of all IPD cases, 61.4 and 79.5% of cases in children under twoyears, and 60.4 and 78.6% of cases involving children under fiveyears of age, respectively. The PCV13 and 23-valent polysaccharide vaccine covered 68.7 and 86.0% of cases in adults >65years old, respectively. Decreased susceptibility was noted for penicillin (24.8%), cefotaxime (10.0%), meropenem (5.0%), rifampicin (0.8%), chloramphenicol (4.3%), erythromycin (29.7%) and clindamycin (25.6%). Multi-drug resistance characterized 21.6% of the pneumococci tested. Despite deficiencies in the Polish surveillance system and strong underestimation of IPD cases, results of the study showed good theoretical coverage of PCV, which should encourage inclusion of anti-pneumococcal conjugate vaccine into the national immunization program. Springer-Verlag Berlin Heidelberg, 2014 Skoczyńska A. National Reference Centre for Bacterial Meningitis, Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Chełmska 30/34, 00-725, Warsaw, Poland aut Kuch A. National Reference Centre for Bacterial Meningitis, Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Chełmska 30/34, 00-725, Warsaw, Poland aut Sadowy E. Department of Molecular Microbiology, National Medicines Institute, Warsaw, Poland aut Waśko I. National Reference Centre for Bacterial Meningitis, Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Chełmska 30/34, 00-725, Warsaw, Poland aut Markowska M. National Reference Centre for Bacterial Meningitis, Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Chełmska 30/34, 00-725, Warsaw, Poland aut Ronkiewicz P. National Reference Centre for Bacterial Meningitis, Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Chełmska 30/34, 00-725, Warsaw, Poland aut Matynia B. National Reference Centre for Bacterial Meningitis, Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Chełmska 30/34, 00-725, Warsaw, Poland aut Bojarska A. Department of Molecular Microbiology, National Medicines Institute, Warsaw, Poland aut Wasiak K. Department of Microbiology, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland aut Gołębiewska A. National Reference Centre for Bacterial Meningitis, Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Chełmska 30/34, 00-725, Warsaw, Poland aut van der Linden M. German National Reference Center for Streptococci, Department of Medical Microbiology University Hospital RWTH Aachen, Aachen, Germany aut Hryniewicz W. National Reference Centre for Bacterial Meningitis, Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Chełmska 30/34, 00-725, Warsaw, Poland aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/4(2015-04-01), 779-787 0934-9723 34:4<779 2015 34 10096 https://doi.org/10.1007/s10096-014-2283-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-014-2283-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Skoczyńska A. National Reference Centre for Bacterial Meningitis, Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Chełmska 30/34, 00-725, Warsaw, Poland aut NATIONALLICENCE 700 1- Kuch A. National Reference Centre for Bacterial Meningitis, Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Chełmska 30/34, 00-725, Warsaw, Poland aut NATIONALLICENCE 700 1- Sadowy E. Department of Molecular Microbiology, National Medicines Institute, Warsaw, Poland aut NATIONALLICENCE 700 1- Waśko I. National Reference Centre for Bacterial Meningitis, Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Chełmska 30/34, 00-725, Warsaw, Poland aut NATIONALLICENCE 700 1- Markowska M. National Reference Centre for Bacterial Meningitis, Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Chełmska 30/34, 00-725, Warsaw, Poland aut NATIONALLICENCE 700 1- Ronkiewicz P. National Reference Centre for Bacterial Meningitis, Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Chełmska 30/34, 00-725, Warsaw, Poland aut NATIONALLICENCE 700 1- Matynia B. National Reference Centre for Bacterial Meningitis, Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Chełmska 30/34, 00-725, Warsaw, Poland aut NATIONALLICENCE 700 1- Bojarska A. Department of Molecular Microbiology, National Medicines Institute, Warsaw, Poland aut NATIONALLICENCE 700 1- Wasiak K. Department of Microbiology, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland aut NATIONALLICENCE 700 1- Gołębiewska A. National Reference Centre for Bacterial Meningitis, Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Chełmska 30/34, 00-725, Warsaw, Poland aut NATIONALLICENCE 700 1- van der Linden M. German National Reference Center for Streptococci, Department of Medical Microbiology University Hospital RWTH Aachen, Aachen, Germany aut NATIONALLICENCE 700 1- Hryniewicz W. National Reference Centre for Bacterial Meningitis, Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Chełmska 30/34, 00-725, Warsaw, Poland aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/4(2015-04-01), 779-787 0934-9723 34:4<779 2015 34 10096