caa a22 4500 606157131 CHVBK 20210128100612.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10096-014-2282-9 doi (NATIONALLICENCE)springer-10.1007/s10096-014-2282-9 Specific antibody responses as indicators of treatment efficacy for visceral leishmaniasis [Elektronische Daten] [A. Vallur, A. Hailu, D. Mondal, C. Reinhart, H. Wondimu, Y. Tutterrow, H. Ghalib, S. Reed, M. Duthie] Acute visceral leishmaniasis (VL) is caused by infection with parasites of the Leishmania donovani complex and may be fatal if not treated. Early diagnosis and efficacious treatment are the keys to effective VL management and control. Novel regimens are being developed to overcome limitations in VL treatment options, which are currently restricted by high costs, severe systemic side effects, and unresponsiveness. Although simple and accurate serological tests are available to help confirm VL, none are suitable to monitor treatment efficacy and cure. Here, we confirm that serum antibody responses to the diagnostic antigens rK39 and rK28 are unaltered by treatment, but demonstrate that antibodies produced against two antigens, rK26 and rK18, can be used as an indirect measure of parasite clearance. The levels of anti-rK18 and -rK26 antibodies were high in patients at initial diagnosis but declined in patients treated with either SSG (Ethiopia) or AmBisome™ (Bangladesh). Taken together, we propose that serological tests which measure antibodies to rK26 and rK18 merit consideration as potential markers of treatment success and cure. Springer-Verlag Berlin Heidelberg, 2014 Vallur A. Infectious Disease Research Institute (IDRI), 1616 Eastlake Avenue E, Suite 400, 98102, Seattle, WA, USA aut Hailu A. Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia aut Mondal D. Laboratory Sciences Division, International Center for Diarrhoeal Diseases Research, Dhaka, Bangladesh aut Reinhart C. Infectious Disease Research Institute (IDRI), 1616 Eastlake Avenue E, Suite 400, 98102, Seattle, WA, USA aut Wondimu H. Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia aut Tutterrow Y. Infectious Disease Research Institute (IDRI), 1616 Eastlake Avenue E, Suite 400, 98102, Seattle, WA, USA aut Ghalib H. Infectious Disease Research Institute (IDRI), 1616 Eastlake Avenue E, Suite 400, 98102, Seattle, WA, USA aut Reed S. Infectious Disease Research Institute (IDRI), 1616 Eastlake Avenue E, Suite 400, 98102, Seattle, WA, USA aut Duthie M. Infectious Disease Research Institute (IDRI), 1616 Eastlake Avenue E, Suite 400, 98102, Seattle, WA, USA aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/4(2015-04-01), 679-686 0934-9723 34:4<679 2015 34 10096 https://doi.org/10.1007/s10096-014-2282-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-014-2282-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vallur A. Infectious Disease Research Institute (IDRI), 1616 Eastlake Avenue E, Suite 400, 98102, Seattle, WA, USA aut NATIONALLICENCE 700 1- Hailu A. Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia aut NATIONALLICENCE 700 1- Mondal D. Laboratory Sciences Division, International Center for Diarrhoeal Diseases Research, Dhaka, Bangladesh aut NATIONALLICENCE 700 1- Reinhart C. Infectious Disease Research Institute (IDRI), 1616 Eastlake Avenue E, Suite 400, 98102, Seattle, WA, USA aut NATIONALLICENCE 700 1- Wondimu H. Department of Microbiology, Immunology and Parasitology, Addis Ababa University, Addis Ababa, Ethiopia aut NATIONALLICENCE 700 1- Tutterrow Y. Infectious Disease Research Institute (IDRI), 1616 Eastlake Avenue E, Suite 400, 98102, Seattle, WA, USA aut NATIONALLICENCE 700 1- Ghalib H. Infectious Disease Research Institute (IDRI), 1616 Eastlake Avenue E, Suite 400, 98102, Seattle, WA, USA aut NATIONALLICENCE 700 1- Reed S. Infectious Disease Research Institute (IDRI), 1616 Eastlake Avenue E, Suite 400, 98102, Seattle, WA, USA aut NATIONALLICENCE 700 1- Duthie M. Infectious Disease Research Institute (IDRI), 1616 Eastlake Avenue E, Suite 400, 98102, Seattle, WA, USA aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/4(2015-04-01), 679-686 0934-9723 34:4<679 2015 34 10096