caa a22 4500 606157204 CHVBK 20210128100612.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10096-015-2395-9 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2395-9 Molecular epidemiology of community-onset methicillin-resistant Staphylococcus aureus infections in Israel [Elektronische Daten] [A. Biber, M. Parizade, D. Taran, H. Jaber, E. Berla, C. Rubin, G. Rahav, D. Glikman, G. Regev-Yochay] Data on community-associated (CA) methicillin-resistant Staphylococcus aureus (MRSA) in Israel are scarce. The objective of this study was to characterize the major CA-MRSA clones in Israel. All clinical MRSA isolates detected in the community during a period of 2.5years (2011-2013) from individuals insured by a major health maintenance organization in Israel were collected, with additional data from medical records. Antibiotic susceptibility patterns and staphylococcal chromosomal cassette mec (SCCmec) typing were determined. SCCmec IV and V isolates were further typed by pulsed-field gel electrophoresis (PFGE), spa typing, and detection of a panel of toxin genes. MRSA were detected in 280 patients, mostly from skin infections. Patients with SCCmec IV (n = 120, 43%) were younger (p < 0.0001) and reported less contact with healthcare facilities. Almost all isolates were trimethoprim-sulfamethoxazole susceptible (98%). spa-CC032, a typical nosocomial MRSA clone, accounted for 28% of SCCmec IV. The two major CA-MRSA clones were t008 USA300 (13%) and t991 (10%); t991 was isolated mainly from children (75%), was Panton-Valentine leukocidin (PVL) negative but eta-positive, and was typically susceptible to most antibiotic groups. PVL-positive strains (n = 31) included mainly USA300 (52%) and t019 (13%). While multiple genetic lineages were evident among community-onset MRSA in Israel, approximately 20% are typical CA-MRSA clones, mainly USA300 and a local clone, t991. Springer-Verlag Berlin Heidelberg, 2015 Biber A. Infectious Dis. Unit, Sheba Medical Center, Ramat-Gan, The Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel aut Parizade M. Central Laboratory, Maccabi Healthcare Services, Rehovot, Israel aut Taran D. Central Laboratory, Maccabi Healthcare Services, Rehovot, Israel aut Jaber H. Infectious Dis. Unit, Sheba Medical Center, Ramat-Gan, The Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel aut Berla E. The Faculty of Medicine, The Hebrew University, Jerusalem, Israel aut Rubin C. Infectious Dis. Epidemiology Section, Gertner Institute, Ramat-Gan, Israel aut Rahav G. Infectious Dis. Unit, Sheba Medical Center, Ramat-Gan, The Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel aut Glikman D. Pediatric Infectious Dis. Service, Galilee Medical Center, Nahariya, The Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel aut Regev-Yochay G. Infectious Dis. Unit, Sheba Medical Center, Ramat-Gan, The Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/8(2015-08-01), 1603-1613 0934-9723 34:8<1603 2015 34 10096 https://doi.org/10.1007/s10096-015-2395-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2395-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Biber A. Infectious Dis. Unit, Sheba Medical Center, Ramat-Gan, The Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel aut NATIONALLICENCE 700 1- Parizade M. Central Laboratory, Maccabi Healthcare Services, Rehovot, Israel aut NATIONALLICENCE 700 1- Taran D. Central Laboratory, Maccabi Healthcare Services, Rehovot, Israel aut NATIONALLICENCE 700 1- Jaber H. Infectious Dis. Unit, Sheba Medical Center, Ramat-Gan, The Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel aut NATIONALLICENCE 700 1- Berla E. The Faculty of Medicine, The Hebrew University, Jerusalem, Israel aut NATIONALLICENCE 700 1- Rubin C. Infectious Dis. Epidemiology Section, Gertner Institute, Ramat-Gan, Israel aut NATIONALLICENCE 700 1- Rahav G. Infectious Dis. Unit, Sheba Medical Center, Ramat-Gan, The Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel aut NATIONALLICENCE 700 1- Glikman D. Pediatric Infectious Dis. Service, Galilee Medical Center, Nahariya, The Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel aut NATIONALLICENCE 700 1- Regev-Yochay G. Infectious Dis. Unit, Sheba Medical Center, Ramat-Gan, The Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/8(2015-08-01), 1603-1613 0934-9723 34:8<1603 2015 34 10096