caa a22 4500 606157344 CHVBK 20210128100613.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10096-015-2382-1 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2382-1 Burkholderia gladioli infection isolated from the blood cultures of newborns in the neonatal intensive care unit [Elektronische Daten] [F. Zhou, H. Ning, F. Chen, W. Wu, A. Chen, J. Zhang] Burkholderia gladioli was described as a plant pathogen, and it is a rare cause of infection in humans that is primarily associated with human pulmonary infections, such as chronic granulomatous disease and cystic fibrosis. The neonatal respiratory system is not fully developed and cannot expel bacterial aerosol properly. A total of 2,676 newborns in the neonatal intensive care unit were retrospectively analysed in Putian City, Fujian Province, China, from 2011 to 2014. All of the blood samples were tested for C-reactive protein (CRP), procalcitonin (PCT) and white blood cell (WBC). B. gladioli infections were determined and analysed using a blood culture system. Antibiotic susceptibility testing was performed using the K-B method. Of the 2,676 participants, 87 (3.25%) had a positive B. gladioli blood culture that occurred >72h after birth, including a premature group (54.0%, asphyxia [vs. 9.20%], fever [vs. 13.80%], pneumonia [vs. 6.90%] and hyperbilirubinaemia [vs. 8.05%]) and newborns with necrotising enterocolitis (NEC) (vs. 5.75%). The mean ± standard deviation (SD) of the CRP level was 12.31 ± 0.26mg/L and that of the PCT level was 1.53 ± 0.21ng/ml in the 87 B. gladioli-infected newborns. Most of the B. gladioli isolates were sensitive to many antimicrobial agents and did not lead to serious consequences. All of the B. gladioli-infected newborns were unhealthy, especially the premature infants. B. gladioli might be a causative bacteraemia agent in neonates, it appears to have pathogenic potential in newborns and its sensitivity to antibiotics may be a beneficial factor. Springer-Verlag Berlin Heidelberg, 2015 Zhou F. Department of Clinical Laboratory, Fujian Medical University Teaching Hospital, First Hospital of Putian, 351100, Putian, China aut Ning H. The Workers and Staff Hospital of HangZhou Steel Group Corp., 310022, Hangzhou, China aut Chen F. Department of Clinical Laboratory, Fujian Medical University Teaching Hospital, First Hospital of Putian, 351100, Putian, China aut Wu W. Department of Clinical Laboratory, Fujian Medical University Teaching Hospital, First Hospital of Putian, 351100, Putian, China aut Chen A. Department of Clinical Laboratory, Fujian Medical University Teaching Hospital, First Hospital of Putian, 351100, Putian, China aut Zhang J. The People's Hospital of Yuxi, 653100, Yuxi, Yunnan, China aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/8(2015-08-01), 1533-1537 0934-9723 34:8<1533 2015 34 10096 https://doi.org/10.1007/s10096-015-2382-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2382-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhou F. Department of Clinical Laboratory, Fujian Medical University Teaching Hospital, First Hospital of Putian, 351100, Putian, China aut NATIONALLICENCE 700 1- Ning H. The Workers and Staff Hospital of HangZhou Steel Group Corp., 310022, Hangzhou, China aut NATIONALLICENCE 700 1- Chen F. Department of Clinical Laboratory, Fujian Medical University Teaching Hospital, First Hospital of Putian, 351100, Putian, China aut NATIONALLICENCE 700 1- Wu W. Department of Clinical Laboratory, Fujian Medical University Teaching Hospital, First Hospital of Putian, 351100, Putian, China aut NATIONALLICENCE 700 1- Chen A. Department of Clinical Laboratory, Fujian Medical University Teaching Hospital, First Hospital of Putian, 351100, Putian, China aut NATIONALLICENCE 700 1- Zhang J. The People's Hospital of Yuxi, 653100, Yuxi, Yunnan, China aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/8(2015-08-01), 1533-1537 0934-9723 34:8<1533 2015 34 10096