caa a22 4500 606157387 CHVBK 20210128100613.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10096-015-2404-z doi (NATIONALLICENCE)springer-10.1007/s10096-015-2404-z Influence of daily dosage and frequency of administration of rifampicin-levofloxacin therapy on tolerance and effectiveness in 154 patients treated for prosthetic joint infections [Elektronische Daten] [S. Nguyen, O. Robineau, M. Titecat, N. Blondiaux, M. Valette, C. Loiez, E. Beltrand, H. Migaud, E. Senneville] Data on the tolerance and effectiveness of rifampicin-levofloxacin combination therapy (RLCT) in patients treated for prosthetic joint infections (PJIs) according to daily dosage are lacking. A review of the clinical data from patients treated with RLCT for PJIs in a French referent center for PJIs was conducted. A total of 154 patients (75F/79M), with a median age of 64.1years and median body weight of 83.1kg, were included. The median daily dosages of rifampicin and levofloxacin were, respectively, 1,200mg (range 300-2,100) and 750mg (range 500-1,500), corresponding to a mean daily dose per kg of, respectively, 16.2 ± 4.3mg/kg and 10.1 ± 3.0mg/kg. After a mean follow-up period of 55.6 ± 27.1months (range 24-236), 127 patients (82.5%) were in remission. Adverse events attributable to rifampicin and levofloxacin were reported in 48 (31.2%) and 13 (8.4%) patients (p < 0.001), respectively. Patients who experienced rifampicin-related adverse events had been given higher rifampicin daily doses than the other patients (p = 0.04). The rifampicin daily dosage did not influence patient outcome and nor did the levofloxacin daily dosage on both tolerance and patient outcome. Our results suggest that adjusting rifampicin daily doses to the patient total body weight when combined with levofloxacin for the treatment of PJIs is associated with a poor tolerance. High daily doses of rifampicin (>600mg) and levofloxacin (750mg) do not improve patient outcome when compared to lower daily doses in this setting. Springer-Verlag Berlin Heidelberg, 2015 Nguyen S. Infectious Diseases Department, Gustave Dron Hospital, 135 rue du Président Coty, 59200, Tourcoing, France aut Robineau O. Infectious Diseases Department, Gustave Dron Hospital, 135 rue du Président Coty, 59200, Tourcoing, France aut Titecat M. Laboratory of Microbiology, University Hospital of Lille, Lille, France aut Blondiaux N. Infectious Diseases Department, Gustave Dron Hospital, 135 rue du Président Coty, 59200, Tourcoing, France aut Valette M. Infectious Diseases Department, Gustave Dron Hospital, 135 rue du Président Coty, 59200, Tourcoing, France aut Loiez C. Laboratory of Microbiology, University Hospital of Lille, Lille, France aut Beltrand E. Orthopaedic Surgery Unit, Gustave Dron Hospital, Tourcoing, France aut Migaud H. Orthopedic Surgery Unit, Roger Salengro Hospital, University Hospital of Lille, Lille, France aut Senneville E. Infectious Diseases Department, Gustave Dron Hospital, 135 rue du Président Coty, 59200, Tourcoing, France aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/8(2015-08-01), 1675-1682 0934-9723 34:8<1675 2015 34 10096 https://doi.org/10.1007/s10096-015-2404-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2404-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nguyen S. Infectious Diseases Department, Gustave Dron Hospital, 135 rue du Président Coty, 59200, Tourcoing, France aut NATIONALLICENCE 700 1- Robineau O. Infectious Diseases Department, Gustave Dron Hospital, 135 rue du Président Coty, 59200, Tourcoing, France aut NATIONALLICENCE 700 1- Titecat M. Laboratory of Microbiology, University Hospital of Lille, Lille, France aut NATIONALLICENCE 700 1- Blondiaux N. Infectious Diseases Department, Gustave Dron Hospital, 135 rue du Président Coty, 59200, Tourcoing, France aut NATIONALLICENCE 700 1- Valette M. Infectious Diseases Department, Gustave Dron Hospital, 135 rue du Président Coty, 59200, Tourcoing, France aut NATIONALLICENCE 700 1- Loiez C. Laboratory of Microbiology, University Hospital of Lille, Lille, France aut NATIONALLICENCE 700 1- Beltrand E. Orthopaedic Surgery Unit, Gustave Dron Hospital, Tourcoing, France aut NATIONALLICENCE 700 1- Migaud H. Orthopedic Surgery Unit, Roger Salengro Hospital, University Hospital of Lille, Lille, France aut NATIONALLICENCE 700 1- Senneville E. Infectious Diseases Department, Gustave Dron Hospital, 135 rue du Président Coty, 59200, Tourcoing, France aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/8(2015-08-01), 1675-1682 0934-9723 34:8<1675 2015 34 10096