caa a22 4500 606157433 CHVBK 20210128100613.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10096-015-2402-1 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2402-1 Differences between endocarditis caused by Streptococcus bovis and Enterococcus spp. and their association with colorectal cancer [Elektronische Daten] [J. Corredoira, M. García-País, A. Coira, R. Rabuñal, F. García-Garrote, J. Pita, A. Rodríguez-Macías, M. Blanco, L. Lopez-Roses, M.J. López-Álvarez, M. P. Alonso-García] Streptococcus bovis group and Enterococcus spp. share phenotypic characteristics and intestinal habitat. Both have been associated with endocarditis and colorectal neoplasm (CRN). We studied all cases of endocarditis diagnosed between 1988 and 2014 in our centre and caused by S. bovis (109, 48.8 % of the bacteremia) and by Enterococcus spp. (36, 3.4 % of the bacteremia). Patients were seen until death or during a long-term follow-up, in order to rule out a concomitant CRN. The 109 cases of S. bovis endocarditis (SbIE) compared with the 36 caused by enterococci showed: a higher proportion of males (91 % vs. 72 %, p=0.005), more multivalvular involvement (28 % vs. 6 %, p=0.004), embolic complications (44 vs. 22 %, p=0.02) and colorectal neoplasm (64 % vs. 25 %, p=0.001). SbIE showed fewer co-morbidities (32 vs. 58 %, p=0.005), and less frequently urinary infection source (0 vs. 25 %, p=0.001) and healthcare-related infection (2 vs. 44 %, p=0.001). A total of 123 patients were followed up for an extended period (mean: 65.9 ± 57.5 months). During the follow-up, 6 of 28 (21 %) cases with enterococcal endocarditis and 43 of 95 (45.2 %, p=0.01) cases with SbIE developed a new CRN. These neoplasiae appeared a mean of 60.4 months later (range 12-181 months). Among the 43 cases with SbIE and CRN, 12 had had a previously normal colonoscopy and 31 had had a previous CRN and developed a second neoplasm. Cases of SbIE present important differences with those caused by Enterococcus spp. Colonoscopy must be mandatory both in the initial evaluation of SbIE, as during the follow-up period. Springer-Verlag Berlin Heidelberg, 2015 Corredoira J. Infectious Disease Unit, Hospital Universitario Lucus Augusti, Avd. Dr. Ulises Romero s/n, 27003, Lugo, Spain aut García-País M. Infectious Disease Unit, Hospital Universitario Lucus Augusti, Avd. Dr. Ulises Romero s/n, 27003, Lugo, Spain aut Coira A. Department of Clinical Microbiology, Hospital Universitario Lucus Augusti, Avd. Dr. Ulises Romero s/n, 27003, Lugo, Spain aut Rabuñal R. Infectious Disease Unit, Hospital Universitario Lucus Augusti, Avd. Dr. Ulises Romero s/n, 27003, Lugo, Spain aut García-Garrote F. Department of Clinical Microbiology, Hospital Universitario Lucus Augusti, Avd. Dr. Ulises Romero s/n, 27003, Lugo, Spain aut Pita J. Department of Clinical Microbiology, Hospital Universitario Lucus Augusti, Avd. Dr. Ulises Romero s/n, 27003, Lugo, Spain aut Rodríguez-Macías A. Department of Clinical Microbiology, Hospital Universitario Lucus Augusti, Avd. Dr. Ulises Romero s/n, 27003, Lugo, Spain aut Blanco M. Department Microbiology, Veterinary Faculty, Universidad de Santiago, Lugo, Spain aut Lopez-Roses L. Gastroenterology Unit, Hospital Universitario Lucus Augusti, Lugo, Spain aut López-Álvarez M.J. Infectious Disease Unit, Hospital Universitario Lucus Augusti, Avd. Dr. Ulises Romero s/n, 27003, Lugo, Spain aut Alonso-García M. P. Department of Clinical Microbiology, Hospital Universitario Lucus Augusti, Avd. Dr. Ulises Romero s/n, 27003, Lugo, Spain aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/8(2015-08-01), 1657-1665 0934-9723 34:8<1657 2015 34 10096 https://doi.org/10.1007/s10096-015-2402-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2402-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Corredoira J. Infectious Disease Unit, Hospital Universitario Lucus Augusti, Avd. Dr. Ulises Romero s/n, 27003, Lugo, Spain aut NATIONALLICENCE 700 1- García-País M. Infectious Disease Unit, Hospital Universitario Lucus Augusti, Avd. Dr. Ulises Romero s/n, 27003, Lugo, Spain aut NATIONALLICENCE 700 1- Coira A. Department of Clinical Microbiology, Hospital Universitario Lucus Augusti, Avd. Dr. Ulises Romero s/n, 27003, Lugo, Spain aut NATIONALLICENCE 700 1- Rabuñal R. Infectious Disease Unit, Hospital Universitario Lucus Augusti, Avd. Dr. Ulises Romero s/n, 27003, Lugo, Spain aut NATIONALLICENCE 700 1- García-Garrote F. Department of Clinical Microbiology, Hospital Universitario Lucus Augusti, Avd. Dr. Ulises Romero s/n, 27003, Lugo, Spain aut NATIONALLICENCE 700 1- Pita J. Department of Clinical Microbiology, Hospital Universitario Lucus Augusti, Avd. Dr. Ulises Romero s/n, 27003, Lugo, Spain aut NATIONALLICENCE 700 1- Rodríguez-Macías A. Department of Clinical Microbiology, Hospital Universitario Lucus Augusti, Avd. Dr. Ulises Romero s/n, 27003, Lugo, Spain aut NATIONALLICENCE 700 1- Blanco M. Department Microbiology, Veterinary Faculty, Universidad de Santiago, Lugo, Spain aut NATIONALLICENCE 700 1- Lopez-Roses L. Gastroenterology Unit, Hospital Universitario Lucus Augusti, Lugo, Spain aut NATIONALLICENCE 700 1- López-Álvarez M.J. Infectious Disease Unit, Hospital Universitario Lucus Augusti, Avd. Dr. Ulises Romero s/n, 27003, Lugo, Spain aut NATIONALLICENCE 700 1- Alonso-García M. P. Department of Clinical Microbiology, Hospital Universitario Lucus Augusti, Avd. Dr. Ulises Romero s/n, 27003, Lugo, Spain aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/8(2015-08-01), 1657-1665 0934-9723 34:8<1657 2015 34 10096