caa a22 4500 606157522 CHVBK 20210128100614.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10096-014-2310-9 doi (NATIONALLICENCE)springer-10.1007/s10096-014-2310-9 Single nucleotide polymorphisms in immune response genes in acute Q fever cases with differences in self-reported symptoms [Elektronische Daten] [C. Wielders, V. Hackert, B. Schimmer, H. Hodemaekers, A. de Klerk, C. Hoebe, P. Schneeberger, Y. van Duynhoven, R. Janssen] Genes involved in human immune response are well recognized to influence the clinical course of infection. The association of host genetics with susceptibility to and severity of clinical symptoms in acute Q fever was investigated. Single nucleotide polymorphisms (SNPs) in the IFNG (rs2430561/rs1861493), STAT1 (rs1914408), and VDR (rs2228570) genes were determined in 85 patients from the 2007 Dutch acute Q fever outbreak, and a symptom score was calculated. IFNG rs1861493 showed a significant association with the symptom score; IFNG rs2430561 showed a similar trend. These SNPs were then used to reproduce results in a 2009 outbreak population (n = 123). The median symptom score differed significantly in both populations: 2 versus 7. The significant association of IFNG rs1861493 with symptom score in the first population was not reproduced in the second population. We hypothesize that individuals in the second outbreak were exposed to a higher Coxiella burnetii dose compared to the first, which overruled the protection conferred by the A-allele of IFNG rs1861493 in the first population. Springer-Verlag Berlin Heidelberg, 2015 Wielders C. Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, P.O. Box 90153, 5200 ME, 's-Hertogenbosch, The Netherlands aut Hackert V. Department of Sexual Health, Infectious Diseases, and Environmental Health, South Limburg Public Health Service, P.O. Box 2022, 6160 HA, Geleen, The Netherlands aut Schimmer B. Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands aut Hodemaekers H. Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands aut de Klerk A. Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands aut Hoebe C. Department of Sexual Health, Infectious Diseases, and Environmental Health, South Limburg Public Health Service, P.O. Box 2022, 6160 HA, Geleen, The Netherlands aut Schneeberger P. Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, P.O. Box 90153, 5200 ME, 's-Hertogenbosch, The Netherlands aut van Duynhoven Y. Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands aut Janssen R. Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/5(2015-05-01), 943-950 0934-9723 34:5<943 2015 34 10096 https://doi.org/10.1007/s10096-014-2310-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-014-2310-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wielders C. Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, P.O. Box 90153, 5200 ME, 's-Hertogenbosch, The Netherlands aut NATIONALLICENCE 700 1- Hackert V. Department of Sexual Health, Infectious Diseases, and Environmental Health, South Limburg Public Health Service, P.O. Box 2022, 6160 HA, Geleen, The Netherlands aut NATIONALLICENCE 700 1- Schimmer B. Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands aut NATIONALLICENCE 700 1- Hodemaekers H. Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands aut NATIONALLICENCE 700 1- de Klerk A. Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands aut NATIONALLICENCE 700 1- Hoebe C. Department of Sexual Health, Infectious Diseases, and Environmental Health, South Limburg Public Health Service, P.O. Box 2022, 6160 HA, Geleen, The Netherlands aut NATIONALLICENCE 700 1- Schneeberger P. Department of Medical Microbiology and Infection Control, Jeroen Bosch Hospital, P.O. Box 90153, 5200 ME, 's-Hertogenbosch, The Netherlands aut NATIONALLICENCE 700 1- van Duynhoven Y. Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands aut NATIONALLICENCE 700 1- Janssen R. Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA, Bilthoven, The Netherlands aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/5(2015-05-01), 943-950 0934-9723 34:5<943 2015 34 10096