caa a22 4500 606157557 CHVBK 20210128100614.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10096-014-2308-3 doi (NATIONALLICENCE)springer-10.1007/s10096-014-2308-3 The incidence of Staphylococcus aureus ST8-USA300 among French pediatric inpatients is rising [Elektronische Daten] [N. van der Mee-Marquet, D.-M. Poisson, J.-P. Lavigne, T. Francia, A. Tristan, F. Vandenesch, R. Quentin, X. Bertrand] Methicillin-resistant Staphylococcus aureus (MRSA) formerly colonized and infected only inpatients in hospitals, but have been reported in community settings worldwide over the last 20years. In France, the prevalence of such MRSA remains low and outbreaks have, until now, been mainly due to the ST80 clone. However, there were two outbreaks of MRSA clone ST-USA300 recently in France, including one involving children. To investigate epidemiological developments, we studied the 77 MRSA isolated from pediatric patients hospitalized between 2008 and 2013 in three French hospitals. The median incidence of MRSA was stable and low (0.137 per 100 admissions). The prevalence of Panton-Valentine leukocidin (PVL)-positive MRSA was high (33.8%). The 26 PVL-positive MRSA were genetically diverse, with two clones being predominant: ST80 (12 isolates, 46.1%) and ST8-USA300 (8 isolates, 30.8%). The incidence of ST8-USA300 increased over the 6-year period. We believe that screening for ST8-USA300 should be improved: medical biologists should be encouraged to search for PVL genes in all MRSA isolates recovered from abscesses, whatever the susceptibility pattern of the isolate, and not only when suggestive of ST80. Springer-Verlag Berlin Heidelberg, 2015 van der Mee-Marquet N. Service de Bactériologie et Hygiène, Hôpital Trousseau, Centre Hospitalier Régional Universitaire, 37044, Tours, France aut Poisson D.-M Laboratoire de Bactériologie, Centre Hospitalier Régional, 45000, Orléans, France aut Lavigne J.-P Laboratoire de Bactériologie, Centre Hospitalier Régional Universitaire Caremeau, 30029, Nîmes, France aut Francia T. Réseau de Hygiénistes du Centre, Hôpital Trousseau, Centre Hospitalier Régional Universitaire, 37044, Tours, France aut Tristan A. Laboratoire de Bactériologie, Centre National de Référence des Staphylocoques, Centre Hospitalier Régional Universitaire, 69003, Lyon, France aut Vandenesch F. Laboratoire de Bactériologie, Centre National de Référence des Staphylocoques, Centre Hospitalier Régional Universitaire, 69003, Lyon, France aut Quentin R. Service de Bactériologie et Hygiène, Hôpital Trousseau, Centre Hospitalier Régional Universitaire, 37044, Tours, France aut Bertrand X. Service d'Hygiène, Centre Hospitalier Régional Universitaire, 25030, Besançon, France aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/5(2015-05-01), 935-942 0934-9723 34:5<935 2015 34 10096 https://doi.org/10.1007/s10096-014-2308-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-014-2308-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van der Mee-Marquet N. Service de Bactériologie et Hygiène, Hôpital Trousseau, Centre Hospitalier Régional Universitaire, 37044, Tours, France aut NATIONALLICENCE 700 1- Poisson D.-M Laboratoire de Bactériologie, Centre Hospitalier Régional, 45000, Orléans, France aut NATIONALLICENCE 700 1- Lavigne J.-P Laboratoire de Bactériologie, Centre Hospitalier Régional Universitaire Caremeau, 30029, Nîmes, France aut NATIONALLICENCE 700 1- Francia T. Réseau de Hygiénistes du Centre, Hôpital Trousseau, Centre Hospitalier Régional Universitaire, 37044, Tours, France aut NATIONALLICENCE 700 1- Tristan A. Laboratoire de Bactériologie, Centre National de Référence des Staphylocoques, Centre Hospitalier Régional Universitaire, 69003, Lyon, France aut NATIONALLICENCE 700 1- Vandenesch F. Laboratoire de Bactériologie, Centre National de Référence des Staphylocoques, Centre Hospitalier Régional Universitaire, 69003, Lyon, France aut NATIONALLICENCE 700 1- Quentin R. Service de Bactériologie et Hygiène, Hôpital Trousseau, Centre Hospitalier Régional Universitaire, 37044, Tours, France aut NATIONALLICENCE 700 1- Bertrand X. Service d'Hygiène, Centre Hospitalier Régional Universitaire, 25030, Besançon, France aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/5(2015-05-01), 935-942 0934-9723 34:5<935 2015 34 10096