caa a22 4500 60615759X CHVBK 20210128100614.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10096-015-2315-z doi (NATIONALLICENCE)springer-10.1007/s10096-015-2315-z Probiotics in addition to antibiotics for the treatment of acute tonsillitis: a randomized, placebo-controlled study [Elektronische Daten] [P. Gilbey, L. Livshits, A. Sharabi-Nov, Y. Avraham, D. Miron] Probiotics are live microorganisms which, when administered in adequate amounts, confer a health benefit on the host. The probiotic Streptococcus salivarius has been shown to be effective in reducing the frequency of recurrent pharyngeal infections in children and adult populations. However, probiotics have not yet been evaluated in the treatment of acute pharyngotonsillitis in adults. We aimed to examine whether the addition of S. salivarius probiotics to the routine therapy of acute pharyngotonsillitis in adult patients may shorten disease duration and reduce symptom severity. This study was a prospective, randomized, placebo-controlled, double-blinded study comparing treatment with probiotics to placebo in addition to antibiotics in patients who were hospitalized with severe pharyngotonsillitis. Laboratory results, pain levels, body temperature, and daily volume of fluids consumed were recorded for both groups. Sixty participants were recruited, 30 for each group. No statistically significant differences between the two groups were observed regarding any of the major clinical and laboratory parameters examined. Supplement probiotic treatment with S. salivarius in patients with acute pharyngotonsillitis treated with penicillin is ineffective in relation to the parameters examined in this study and we cannot, therefore, recommend the use of S. salivarius during active pharyngotonsillar infection treated with penicillin. Springer-Verlag Berlin Heidelberg, 2015 Gilbey P. Otolaryngology, Head & Neck Surgery Unit, Ziv Medical Center, Rambam St., 13100, Safed, Israel aut Livshits L. Otolaryngology, Head & Neck Surgery Unit, Ziv Medical Center, Rambam St., 13100, Safed, Israel aut Sharabi-Nov A. Research Wing, Ziv Medical Center, Safed, Israel aut Avraham Y. Otolaryngology, Head & Neck Surgery Unit, Ziv Medical Center, Rambam St., 13100, Safed, Israel aut Miron D. The Infectious Disease Consultation Service, Ziv Medical Center, Safed, Israel aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/5(2015-05-01), 1011-1015 0934-9723 34:5<1011 2015 34 10096 https://doi.org/10.1007/s10096-015-2315-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2315-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gilbey P. Otolaryngology, Head & Neck Surgery Unit, Ziv Medical Center, Rambam St., 13100, Safed, Israel aut NATIONALLICENCE 700 1- Livshits L. Otolaryngology, Head & Neck Surgery Unit, Ziv Medical Center, Rambam St., 13100, Safed, Israel aut NATIONALLICENCE 700 1- Sharabi-Nov A. Research Wing, Ziv Medical Center, Safed, Israel aut NATIONALLICENCE 700 1- Avraham Y. Otolaryngology, Head & Neck Surgery Unit, Ziv Medical Center, Rambam St., 13100, Safed, Israel aut NATIONALLICENCE 700 1- Miron D. The Infectious Disease Consultation Service, Ziv Medical Center, Safed, Israel aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/5(2015-05-01), 1011-1015 0934-9723 34:5<1011 2015 34 10096