caa a22 4500 606157603 CHVBK 20210128100614.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10096-015-2319-8 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2319-8 High medical impact of implementing the new polymeric bead-based BacT/ALERT® FAPlus and FNPlus blood culture bottles in standard care [Elektronische Daten] [R. Amarsy-Guerle, F. Mougari, H. Jacquier, J. Oliary, H. Benmansour, J. Riahi, B. Berçot, L. Raskine, E. Cambau] Blood culture (BC) efficiency is critical for the diagnosis of bloodstream infection (BSI). We evaluated the impact on standard care of implementing the new BacT/ALERT® FAPlus and FNPlus BC bottles containing antibiotic-binding polymeric beads. We measured positivity rates and time to detection (TTD) during the first 10months of implementation (PF) and during the previous 10-month period (PS) during which we were using standard aerobic (SA) or standard anaerobic (SN) BC bottles. For each period, the same number of consecutive patients (n = 3,918) was included. Per patient, a median of 1 BC set (1 aerobic and 1 anaerobic bottles) has been sampled. A higher positivity rate was measured during PF than PS when counting per BC bottle (7.0% vs 5.8% with 1,456 and 1,237 positive bottles respectively, P < 0.0001) and per BC set (9.6% vs 7.8% with 995 and 832 positive BC sets respectively, P < 0.0001). In PF, an increased number of cases due to staphylococci (P < 0.0001) and to Gram-negative bacilli (P < 0.005) was observed, whereas the contamination rate was similar during the two periods (2.4% of BC sets in PF and 2.3% in PS). Although antibiotic consumption and medical activity were similar during the two periods, BSI case detection increased from 2.2 to 2.6 per 1,000 hospital-days, especially in intensive care units (ICU; 35.1 to 55.7). Mean TTD for pathogenic microorganisms was significantly shorter in PF than in PS (15.5h vs 18.0h, P < 0.01). In conclusion, the use of the new FAPlus/FNPlus BC bottles improved the diagnosis of bacteremia in our hospital, especially in ICU patients. Springer-Verlag Berlin Heidelberg, 2015 Amarsy-Guerle R. Service de Bactériologie, AP-HP, Hôpital Lariboisière, 75010, Paris, France aut Mougari F. Service de Bactériologie, AP-HP, Hôpital Lariboisière, 75010, Paris, France aut Jacquier H. Service de Bactériologie, AP-HP, Hôpital Lariboisière, 75010, Paris, France aut Oliary J. AP-HP, Hôpital Lariboisière, Pharmacie, 75010, Paris, France aut Benmansour H. Service de Bactériologie, AP-HP, Hôpital Lariboisière, 75010, Paris, France aut Riahi J. Service de Bactériologie, AP-HP, Hôpital Lariboisière, 75010, Paris, France aut Berçot B. Service de Bactériologie, AP-HP, Hôpital Lariboisière, 75010, Paris, France aut Raskine L. Service de Bactériologie, AP-HP, Hôpital Lariboisière, 75010, Paris, France aut Cambau E. Service de Bactériologie, AP-HP, Hôpital Lariboisière, 75010, Paris, France aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/5(2015-05-01), 1031-1037 0934-9723 34:5<1031 2015 34 10096 https://doi.org/10.1007/s10096-015-2319-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2319-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Amarsy-Guerle R. Service de Bactériologie, AP-HP, Hôpital Lariboisière, 75010, Paris, France aut NATIONALLICENCE 700 1- Mougari F. Service de Bactériologie, AP-HP, Hôpital Lariboisière, 75010, Paris, France aut NATIONALLICENCE 700 1- Jacquier H. Service de Bactériologie, AP-HP, Hôpital Lariboisière, 75010, Paris, France aut NATIONALLICENCE 700 1- Oliary J. AP-HP, Hôpital Lariboisière, Pharmacie, 75010, Paris, France aut NATIONALLICENCE 700 1- Benmansour H. Service de Bactériologie, AP-HP, Hôpital Lariboisière, 75010, Paris, France aut NATIONALLICENCE 700 1- Riahi J. Service de Bactériologie, AP-HP, Hôpital Lariboisière, 75010, Paris, France aut NATIONALLICENCE 700 1- Berçot B. Service de Bactériologie, AP-HP, Hôpital Lariboisière, 75010, Paris, France aut NATIONALLICENCE 700 1- Raskine L. Service de Bactériologie, AP-HP, Hôpital Lariboisière, 75010, Paris, France aut NATIONALLICENCE 700 1- Cambau E. Service de Bactériologie, AP-HP, Hôpital Lariboisière, 75010, Paris, France aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/5(2015-05-01), 1031-1037 0934-9723 34:5<1031 2015 34 10096