caa a22 4500 606157646 CHVBK 20210128100614.0 cr unu---uuuuu 210128e20150501xx s 000 0 eng 10.1007/s10096-015-2323-z doi (NATIONALLICENCE)springer-10.1007/s10096-015-2323-z Olsen I. Department of Oral Biology, Faculty of Dentistry, University of Oslo, P.O. Box 1052 Blindern, 0316, Oslo, Norway aut Biofilm-specific antibiotic tolerance and resistance [Elektronische Daten] [I. Olsen] Biofilms are heterogeneous structures composed of bacterial cells surrounded by a matrix and attached to solid surfaces. The bacteria here are 100 to 1,000 times more tolerant to antimicrobials than corresponding planktonic cells. Biofilms can be difficult to eradicate when they cause biofilm-related diseases, e.g., implant infections, cystic fibrosis, urinary tract infections, and periodontal diseases. A number of phenotypic features of the biofilm can be involved in biofilm-specific tolerance and resistance. Little is known about the molecular mechanisms involved. The current review deals with both phenotypic and molecular mechanisms of biofilm-specific antibiotic tolerance and resistance. Springer-Verlag Berlin Heidelberg, 2015 European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/5(2015-05-01), 877-886 0934-9723 34:5<877 2015 34 10096 https://doi.org/10.1007/s10096-015-2323-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2323-z text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Olsen I. Department of Oral Biology, Faculty of Dentistry, University of Oslo, P.O. Box 1052 Blindern, 0316, Oslo, Norway aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/5(2015-05-01), 877-886 0934-9723 34:5<877 2015 34 10096