caa a22 4500 606157751 CHVBK 20210128100615.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s10096-014-2237-1 doi (NATIONALLICENCE)springer-10.1007/s10096-014-2237-1 Predictors of skin and soft tissue infections in HIV-infected outpatients in the community-associated methicillin-resistant Staphylococcus aureus era [Elektronische Daten] [V. Hemmige, M. McNulty, E. Silverman, M. David] Skin and soft tissue infections (SSTIs) are common in the era of community-associated methicillin-resistant Staphylococcus aureus (MRSA) among human immunodeficiency virus (HIV)-infected patients, but the risk factors are not well defined. We sought to elucidate the risk factors for SSTI occurrence in an HIV cohort. This investigation was a retrospective, single-center cohort study, carried out during the period 2005-2009. In this cohort of 511 HIV-infected individuals, 133 SSTIs occurred in 87 individuals over 1,228.6 person-years of follow-up, for an incidence of 108 SSTIs/1,000 person-years [95% confidence interval (CI) 87-135]. The incidence declined significantly over time (p < 0.01). In a multivariable Cox regression, diabetes [hazard ratio (HR) 2.01; 95% CI 1.04-3.89], psoriasis (HR 5.77; 95% CI 1.86-17.9), lymphedema (HR 6.84; 95% CI 2.59-18.1), intravenous catheter presence (HR 3.38; 95% CI 1.00-11.5), and HIV viral load greater than 1,000 copies/mL (HR 2.13; 95% CI 1.33-3.41) were most strongly associated with development of the first SSTI. Trends toward an association between SSTI risk and Medicaid insurance (HR 1.67; 95% CI 0.98-2.83) and sexually transmitted disease during follow-up (HR 1.66; 0.99-2.78) were present. CD4+ count and trimethoprim-sulfamethoxazole use were not associated with SSTI risk. HIV-infected individuals are at high risk for SSTIs. In a primarily urban, African-American cohort, we found that a number of immunologic and demographic factors were associated with SSTI risk. Springer-Verlag Berlin Heidelberg, 2014 Hemmige V. Division of Infectious Diseases, Department of Medicine, Baylor College of Medicine, 6620 Main Street, Suite 1375, 77030, Houston, TX, USA aut McNulty M. Department of Medicine, University of Chicago, Chicago, IL, USA aut Silverman E. Wayne State University School of Medicine, Detroit, MI, USA aut David M. Department of Medicine, University of Chicago, Chicago, IL, USA aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/2(2015-02-01), 339-347 0934-9723 34:2<339 2015 34 10096 https://doi.org/10.1007/s10096-014-2237-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-014-2237-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hemmige V. Division of Infectious Diseases, Department of Medicine, Baylor College of Medicine, 6620 Main Street, Suite 1375, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- McNulty M. Department of Medicine, University of Chicago, Chicago, IL, USA aut NATIONALLICENCE 700 1- Silverman E. Wayne State University School of Medicine, Detroit, MI, USA aut NATIONALLICENCE 700 1- David M. Department of Medicine, University of Chicago, Chicago, IL, USA aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/2(2015-02-01), 339-347 0934-9723 34:2<339 2015 34 10096