caa a22 4500 606157867 CHVBK 20210128100616.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s10096-014-2234-4 doi (NATIONALLICENCE)springer-10.1007/s10096-014-2234-4 Lysophosphatidylcholine as a prognostic marker in community-acquired pneumonia requiring hospitalization: a pilot study [Elektronische Daten] [W. Cho, H. Yeo, S. Yoon, S. Lee, D. Jeon, Y. Kim, S. Lee, E. Jo, J. Mok, M. Kim, K. Kim, K. Lee, H. Park, M. Lee] Clinical prediction indicators such as the pneumonia severity index (PSI) and CURB-65 score are useful, but they are complex and often not followed. Therefore, biomarkers that improve hospital outcome predictions are emerging. This study evaluated the prognostic value of a new sepsis biomarker, serum lysophosphatidylcholine (LPC) concentrations, in community-acquired pneumonia (CAP) patients. We prospectively collected blood samples from emergency department CAP patients on days 1 and 7 (post-admission) and analyzed their plasma LPC concentrations. We retrospectively reviewed patient medical records and analyzed correlations between plasma LPC concentrations and clinical parameters and hospital outcomes. A total of 56 CAP patients were included in this study; 24 (42.9%) required intubation and 15 (26.8%) died. The mean LPC concentrations on days 1 (p = 0.015) and 7 (p = 0.002) of hospitalization were significantly lower in the non-survivors. Day 1 LPC concentrations were inversely correlated with the PSI (ρ = −269) and CURB-65 scores (ρ = −386). For predicting hospital mortality, the day 1 LPC concentration was comparable with the CURB-65 or PSI scores. Day 1 LPC cut-off levels <29.6μmol/L were associated with hospital CAP outcomes, including the need for mechanical ventilation, vasopressors, intensive care unit admission, and hospital mortality. Additionally, day 7 LPC concentrations were correlated with in-hospital mortality. Initial serum LPC concentrations predicted hospital outcomes in CAP patients requiring hospitalization. These values were correlated with prognostic markers, such as the PSI and CURB-65 scores. Additionally, follow-up LPC measurements predicted the clinical course of CAP patients. Springer-Verlag Berlin Heidelberg, 2014 Cho W. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, 626-770, Yangsan-si, Korea aut Yeo H. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, 626-770, Yangsan-si, Korea aut Yoon S. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, 626-770, Yangsan-si, Korea aut Lee S. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, 626-770, Yangsan-si, Korea aut Jeon D. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, 626-770, Yangsan-si, Korea aut Kim Y. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, 626-770, Yangsan-si, Korea aut Jo E. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea aut Mok J. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea aut Kim M. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea aut Kim K. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea aut Lee K. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea aut Park H. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea aut Lee M. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/2(2015-02-01), 309-315 0934-9723 34:2<309 2015 34 10096 https://doi.org/10.1007/s10096-014-2234-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-014-2234-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cho W. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, 626-770, Yangsan-si, Korea aut NATIONALLICENCE 700 1- Yeo H. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, 626-770, Yangsan-si, Korea aut NATIONALLICENCE 700 1- Yoon S. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, 626-770, Yangsan-si, Korea aut NATIONALLICENCE 700 1- Lee S. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, 626-770, Yangsan-si, Korea aut NATIONALLICENCE 700 1- Jeon D. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, 626-770, Yangsan-si, Korea aut NATIONALLICENCE 700 1- Kim Y. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, 626-770, Yangsan-si, Korea aut NATIONALLICENCE 700 1- Jo E. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea aut NATIONALLICENCE 700 1- Mok J. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea aut NATIONALLICENCE 700 1- Kim M. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea aut NATIONALLICENCE 700 1- Kim K. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea aut NATIONALLICENCE 700 1- Lee K. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea aut NATIONALLICENCE 700 1- Park H. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea aut NATIONALLICENCE 700 1- Lee M. Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/2(2015-02-01), 309-315 0934-9723 34:2<309 2015 34 10096