caa a22 4500 606157905 CHVBK 20210128100616.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s10096-014-2226-4 doi (NATIONALLICENCE)springer-10.1007/s10096-014-2226-4 Surgical treatment for pyogenic vertebral osteomyelitis using iodine-supported spinal instruments: initial case series of 14 patients [Elektronische Daten] [S. Demura, H. Murakami, T. Shirai, S. Kato, K. Yoshioka, T. Ota, T. Ishii, T. Igarashi, H. Tsuchiya] Reports have detailed the increasing use of spinal instrumentation in the treatment of pyogenic vertebral osteomyelitis, with the aims of achieving a lower pseudoarthrosis rate and restoring spinal alignment. However, controversy remains over the use of instrumentation in the presence of active infection because of concerns about increased bacterial adherence and biofilm formation on the metallic implant surface. Fourteen consecutive patients were followed who were diagnosed as having pyogenic vertebral osteomyelitis and underwent surgery with spinal instrumentation with iodine-containing surfaces that could be directly supported to existing titanium implants. Bone-cage interfaces and implant-related complications after surgery were evaluated. The white blood cell (WBC) count and C-reactive protein (CRP) level were analyzed during the follow-up period. To confirm the influence of iodine release from the implant, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were also examined. The infection subsided in all 14 patients. Both WBC counts and CRP levels returned to normal ranges by the final follow-up. One patient showed a lucent area around the screw and two patients showed lucencies inside the cage. However, no cage dislocations, cage migrations, or screw pull-outs were noted, and all patients' FT3, FT4, and TSH levels were within normal ranges during the follow-up period. We demonstrated the efficacy of iodine-supported titanium implants in the management of pyogenic vertebral osteomyelitis. No cytotoxicity or adverse effects were noted in this series. Springer-Verlag Berlin Heidelberg, 2014 Demura S. Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, 920-8641, Kanazawa, Japan aut Murakami H. Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, 920-8641, Kanazawa, Japan aut Shirai T. Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, 920-8641, Kanazawa, Japan aut Kato S. Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, 920-8641, Kanazawa, Japan aut Yoshioka K. Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, 920-8641, Kanazawa, Japan aut Ota T. Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, 920-8641, Kanazawa, Japan aut Ishii T. Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, 920-8641, Kanazawa, Japan aut Igarashi T. Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, 920-8641, Kanazawa, Japan aut Tsuchiya H. Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, 920-8641, Kanazawa, Japan aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/2(2015-02-01), 261-266 0934-9723 34:2<261 2015 34 10096 https://doi.org/10.1007/s10096-014-2226-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-014-2226-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Demura S. Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, 920-8641, Kanazawa, Japan aut NATIONALLICENCE 700 1- Murakami H. Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, 920-8641, Kanazawa, Japan aut NATIONALLICENCE 700 1- Shirai T. Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, 920-8641, Kanazawa, Japan aut NATIONALLICENCE 700 1- Kato S. Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, 920-8641, Kanazawa, Japan aut NATIONALLICENCE 700 1- Yoshioka K. Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, 920-8641, Kanazawa, Japan aut NATIONALLICENCE 700 1- Ota T. Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, 920-8641, Kanazawa, Japan aut NATIONALLICENCE 700 1- Ishii T. Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, 920-8641, Kanazawa, Japan aut NATIONALLICENCE 700 1- Igarashi T. Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, 920-8641, Kanazawa, Japan aut NATIONALLICENCE 700 1- Tsuchiya H. Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13-1 Takaramachi, 920-8641, Kanazawa, Japan aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/2(2015-02-01), 261-266 0934-9723 34:2<261 2015 34 10096