caa a22 4500 606158073 CHVBK 20210128100617.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s10096-015-2469-8 doi (NATIONALLICENCE)springer-10.1007/s10096-015-2469-8 Invasive Fusobacterium necrophorum infections and Lemièrre's syndrome: the role of thrombophilia and EBV [Elektronische Daten] [K. Holm, P. Svensson, M. Rasmussen] The purpose of this investigation was to describe the clinical spectrum of invasive Fusobacterium necrophorum infections and Lemièrre's syndrome, to examine the role of underlying thrombophilia and concomitant mononucleosis in Lemièrre's syndrome, and to describe thromboembolic complications. Patients with invasive F. necrophorum infections were identified either prospectively or retrospectively through the regional database of clinical microbiology from 2000 to 2015. Patient records were reviewed and blood samples from patients with Lemièrre's syndrome were collected for Epstein-Barr virus (EBV) serology and screening for thrombophilia. Of the 65 patients included, 33 had Lemièrre's syndrome. Of the remaining 32 patients, other infections of the respiratory tract and abdominal or urogenital infections were most common. Patients with Lemièrre's syndrome or other tonsillar infections were younger than patients from the other groups. For Lemièrre's syndrome, the 26 patients with severe sepsis on admittance had longer duration of symptoms. Three of five patients who developed distant manifestations had more than 14days of symptoms. Jugular vein thrombosis was verified in 14 patients, two of whom developed serious complications. Three of 26 patients tested had factor V Leiden mutation, corresponding to the background prevalence. One of 22 patients tested had a concomitant EBV infection. This study confirms earlier studies of the clinical spectrum caused by F. necrophorum. For Lemièrre's syndrome, the study adds to the knowledge on thromboembolic outcome, demonstrating that jugular vein thrombosis may cause severe complications. The time to treatment seems to be important for the risk of severe disease. In this study, concomitant EBV infection or underlying thrombophilia was uncommon. Springer-Verlag Berlin Heidelberg, 2015 Holm K. Department of Clinical Sciences, Division of Infection Medicine, Lund University, BMC B14, Tornavägen 10, 221 84, Lund, Sweden aut Svensson P. Department for Coagulation Disorders, Skåne University Hospital, Jan Waldenströms gata 14, 205 02, Malmö, Sweden aut Rasmussen M. Department of Clinical Sciences, Division of Infection Medicine, Lund University, BMC B14, Tornavägen 10, 221 84, Lund, Sweden aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/11(2015-11-01), 2199-2207 0934-9723 34:11<2199 2015 34 10096 https://doi.org/10.1007/s10096-015-2469-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2469-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Holm K. Department of Clinical Sciences, Division of Infection Medicine, Lund University, BMC B14, Tornavägen 10, 221 84, Lund, Sweden aut NATIONALLICENCE 700 1- Svensson P. Department for Coagulation Disorders, Skåne University Hospital, Jan Waldenströms gata 14, 205 02, Malmö, Sweden aut NATIONALLICENCE 700 1- Rasmussen M. Department of Clinical Sciences, Division of Infection Medicine, Lund University, BMC B14, Tornavägen 10, 221 84, Lund, Sweden aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/11(2015-11-01), 2199-2207 0934-9723 34:11<2199 2015 34 10096