caa a22 4500 606158111 CHVBK 20210128100617.0 cr unu---uuuuu 210128e20151101xx s 000 0 eng 10.1007/s10096-015-2474-y doi (NATIONALLICENCE)springer-10.1007/s10096-015-2474-y Aspergillus fumigatus chronic colonization and lung function decline in cystic fibrosis may have a two-way relationship [Elektronische Daten] [M. Noni, A. Katelari, G. Dimopoulos, S.-E. Doudounakis, C. Tzoumaka-Bakoula, V. Spoulou] Aspergillus fumigatus is commonly found in cystic fibrosis (CF) airways. Our aim was to assess the relationship between A. fumigatus chronic colonization and lung function in CF patients. A case-control study of CF patients born from 1989 to 2002 was performed. Medical records were reviewed from the time of initial diagnosis until December 2013. Chronic colonization was defined as two or more positive sputum cultures in a given year. Each patient chronically colonized with A. fumigatus was matched with three control patients (never colonized by A. fumigatus) for age, sex, and year of birth (±3years). A number of parameters were recorded and analyzed prospectively. The primary outcome measure was the difference in forced expiratory volume in 1s (FEV1) in percent predicted between groups. Linear mixed models were used for longitudinal analyses to evaluate the relationship between A. fumigatus chronic colonization and lung function during a 7-year period and study the lung function 4years before the time of enrollment (t0). Twenty patients had chronic colonization and were matched with 60 controls. A significant difference in lung function was detected throughout the 7-year period after adjustment for confounders (est = 8.66, p = 0.020). Four years before t0, FEV1 baseline was the only factor associated with the course of lung function (est = 0.64, p < 0.001) and was significantly different between groups (p = 0.001). In conclusion, a decreased FEV1 baseline appears to be a risk factor for chronic colonization by A. fumigatus, which, in turn, may cause a faster deterioration of lung function. Springer-Verlag Berlin Heidelberg, 2015 Noni M. Department of Cystic Fibrosis, "Aghia Sophia” Children's Hospital, Thivon & Papadiamantopoulou, PC 11527, Athens, Greece aut Katelari A. Department of Cystic Fibrosis, "Aghia Sophia” Children's Hospital, Thivon & Papadiamantopoulou, PC 11527, Athens, Greece aut Dimopoulos G. Department of Critical Care, Medical School, University of Athens, University Hospital "Attikon”, Athens, Greece aut Doudounakis S.-E Department of Cystic Fibrosis, "Aghia Sophia” Children's Hospital, Thivon & Papadiamantopoulou, PC 11527, Athens, Greece aut Tzoumaka-Bakoula C. Medical School, University of Athens, Athens, Greece aut Spoulou V. 1st Department of Pediatrics, Medical School, University of Athens, "Aghia Sophia” Children's Hospital, Athens, Greece aut European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/11(2015-11-01), 2235-2241 0934-9723 34:11<2235 2015 34 10096 https://doi.org/10.1007/s10096-015-2474-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10096-015-2474-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Noni M. Department of Cystic Fibrosis, "Aghia Sophia” Children's Hospital, Thivon & Papadiamantopoulou, PC 11527, Athens, Greece aut NATIONALLICENCE 700 1- Katelari A. Department of Cystic Fibrosis, "Aghia Sophia” Children's Hospital, Thivon & Papadiamantopoulou, PC 11527, Athens, Greece aut NATIONALLICENCE 700 1- Dimopoulos G. Department of Critical Care, Medical School, University of Athens, University Hospital "Attikon”, Athens, Greece aut NATIONALLICENCE 700 1- Doudounakis S.-E Department of Cystic Fibrosis, "Aghia Sophia” Children's Hospital, Thivon & Papadiamantopoulou, PC 11527, Athens, Greece aut NATIONALLICENCE 700 1- Tzoumaka-Bakoula C. Medical School, University of Athens, Athens, Greece aut NATIONALLICENCE 700 1- Spoulou V. 1st Department of Pediatrics, Medical School, University of Athens, "Aghia Sophia” Children's Hospital, Athens, Greece aut NATIONALLICENCE 773 0- European Journal of Clinical Microbiology & Infectious Diseases Springer Berlin Heidelberg 34/11(2015-11-01), 2235-2241 0934-9723 34:11<2235 2015 34 10096