caa a22 4500 606158170 CHVBK 20210128100618.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s10557-015-6573-x doi (NATIONALLICENCE)springer-10.1007/s10557-015-6573-x HIV Patients Have Impaired Diastolic Function that is Not Aggravated by Anti-Retroviral Treatment [Elektronische Daten] [Ricardo Fontes-Carvalho, Jennifer Mancio, Acúrcio Marcos, Francisco Sampaio, Margarida Mota, Francisco Rocha Gonçalves, Vasco Gama, Ana Azevedo, Adelino Leite-Moreira] Purpose: Recent studies have shown that HIV infection is independently associated with heart failure. Diastolic dysfunction (DD) is frequent in HIV patients, but it is unclear whether this is an effect of the HIV infection itself or of the anti-retroviral therapy (ART). Our aim was to compare diastolic function in HIV treatment-naïve, HIV-ART patients and controls. Methods: We prospectively enrolled 206 consecutive patients with HIV-1 infection and 30 controls, selected by frequency matching for age and sex. HIV patients were divided in two subgroups: ART-naïve (n = 88) and ART (n = 118). Diastolic function was assessed and graded by echocardiography, according to modern consensus criteria and using tissue Doppler analysis. Results: Compared to controls, ART-naïve patients had lower E' velocities (E' septal: 10.2 ± 2.4 vs 11.9 ± 2.6cm/s, p = 0.02), higher E/E' ratio (7.8 ± 1.9 vs 6.9 ± 1.6,p = 0.02) and higher prevalence of DD (19% vs 3.3%,p = 0.05). HIV patients under ART also had worse diastolic function compared to controls (E' septal: 10.3 ± 2.5cm/s;p < 0.01; E/E'ratio: 8.0 ± 2.0,p < 0.01; DD prevalence: 23%;p = 0.01), but no significant differences were found between ART-naïve and ART HIV subgroups. In multivariable logistic regression analysis, age and body mass index were the only independent predictors of reduced diastolic reserve in HIV patients. Regarding systolic function, there were no significant differences in ejection fraction or S' velocities between controls and HIV subgroups. Conclusions: HIV treatment-naïve patients have reduced diastolic reserve that is not worsened by ART. These data reinforce the association of diastolic dysfunction with the HIV infection itself and not with the anti-retroviral therapy. Springer Science+Business Media New York, 2015 HIV nationallicence Diastole nationallicence Anti-HIV drugs nationallicence Fontes-Carvalho Ricardo Cardiology Department, Gaia Hospital Center, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal aut Mancio Jennifer Cardiology Department, Gaia Hospital Center, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal aut Marcos Acúrcio Cardiology Department, Gaia Hospital Center, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal aut Sampaio Francisco Cardiology Department, Gaia Hospital Center, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal aut Mota Margarida Department of Infectious Diseases, Gaia Hospital Center, Gaia, Portugal aut Rocha Gonçalves Francisco Department of Medicine, Faculty of Medicine, University of Porto, Porto, Portugal aut Gama Vasco Cardiology Department, Gaia Hospital Center, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal aut Azevedo Ana Department of Clinical Epidemiology, Predictive Medicine and Public Health, Faculty of Medicine, University of Porto, Porto, Portugal aut Leite-Moreira Adelino Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Porto, Portugal aut Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/1(2015-02-01), 31-39 0920-3206 29:1<31 2015 29 10557 https://doi.org/10.1007/s10557-015-6573-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10557-015-6573-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fontes-Carvalho Ricardo Cardiology Department, Gaia Hospital Center, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal aut NATIONALLICENCE 700 1- Mancio Jennifer Cardiology Department, Gaia Hospital Center, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal aut NATIONALLICENCE 700 1- Marcos Acúrcio Cardiology Department, Gaia Hospital Center, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal aut NATIONALLICENCE 700 1- Sampaio Francisco Cardiology Department, Gaia Hospital Center, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal aut NATIONALLICENCE 700 1- Mota Margarida Department of Infectious Diseases, Gaia Hospital Center, Gaia, Portugal aut NATIONALLICENCE 700 1- Rocha Gonçalves Francisco Department of Medicine, Faculty of Medicine, University of Porto, Porto, Portugal aut NATIONALLICENCE 700 1- Gama Vasco Cardiology Department, Gaia Hospital Center, Rua Conceição Fernandes, 4434-502, Vila Nova de Gaia, Portugal aut NATIONALLICENCE 700 1- Azevedo Ana Department of Clinical Epidemiology, Predictive Medicine and Public Health, Faculty of Medicine, University of Porto, Porto, Portugal aut NATIONALLICENCE 700 1- Leite-Moreira Adelino Department of Physiology and Cardiothoracic Surgery, Faculty of Medicine, University of Porto, Porto, Portugal aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/1(2015-02-01), 31-39 0920-3206 29:1<31 2015 29 10557