caa a22 4500 606158227 CHVBK 20210128100618.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s10557-014-6568-z doi (NATIONALLICENCE)springer-10.1007/s10557-014-6568-z Post-myocardial Infarct Inflammation and the Potential Role of Cell Therapy [Elektronische Daten] [Vanessa-leigh van Zuylen, Melina den Haan, Sacha Geutskens, Helene Roelofs, Willem Fibbe, Martin Schalij, Douwe Atsma] Myocardial infarction triggers reparative inflammatory processes programmed to repair damaged tissue. However, often additional injury to the myocardium occurs through the course of this inflammatory process, which ultimately can lead to heart failure. The potential beneficial effects of cell therapy in treating cardiac ischemic disease, the number one cause of death worldwide, are being studied extensively, both in clinical trials using adult stem cells as well as in fundamental research on cardiac stem cells and regenerative biology. This review summarizes the current knowledge on molecular and cellular processes implicated in post-infarction inflammation and discusses the potential beneficial role cell therapy might play in this process. Due to its immunomodulatory properties, the mesenchymal stromal cell is a candidate to reverse the disease progression of the infarcted heart towards heart failure, and therefore is emphasized in this review. Springer Science+Business Media New York, 2015 Myocardial infarction nationallicence Inflammatory response nationallicence Cell therapy nationallicence Mesenchymal stromal cell nationallicence van Zuylen Vanessa-leigh Department of Cardiology, Leiden University Medical Center, P.O. Box 9600, 2300, Leiden, RC, The Netherlands aut den Haan Melina Department of Cardiology, Leiden University Medical Center, P.O. Box 9600, 2300, Leiden, RC, The Netherlands aut Geutskens Sacha Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P.O. Box 9600, 2300, Leiden, RC, The Netherlands aut Roelofs Helene Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P.O. Box 9600, 2300, Leiden, RC, The Netherlands aut Fibbe Willem Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P.O. Box 9600, 2300, Leiden, RC, The Netherlands aut Schalij Martin Department of Cardiology, Leiden University Medical Center, P.O. Box 9600, 2300, Leiden, RC, The Netherlands aut Atsma Douwe Department of Cardiology, Leiden University Medical Center, P.O. Box 9600, 2300, Leiden, RC, The Netherlands aut Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/1(2015-02-01), 59-73 0920-3206 29:1<59 2015 29 10557 https://doi.org/10.1007/s10557-014-6568-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10557-014-6568-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van Zuylen Vanessa-leigh Department of Cardiology, Leiden University Medical Center, P.O. Box 9600, 2300, Leiden, RC, The Netherlands aut NATIONALLICENCE 700 1- den Haan Melina Department of Cardiology, Leiden University Medical Center, P.O. Box 9600, 2300, Leiden, RC, The Netherlands aut NATIONALLICENCE 700 1- Geutskens Sacha Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P.O. Box 9600, 2300, Leiden, RC, The Netherlands aut NATIONALLICENCE 700 1- Roelofs Helene Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P.O. Box 9600, 2300, Leiden, RC, The Netherlands aut NATIONALLICENCE 700 1- Fibbe Willem Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P.O. Box 9600, 2300, Leiden, RC, The Netherlands aut NATIONALLICENCE 700 1- Schalij Martin Department of Cardiology, Leiden University Medical Center, P.O. Box 9600, 2300, Leiden, RC, The Netherlands aut NATIONALLICENCE 700 1- Atsma Douwe Department of Cardiology, Leiden University Medical Center, P.O. Box 9600, 2300, Leiden, RC, The Netherlands aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/1(2015-02-01), 59-73 0920-3206 29:1<59 2015 29 10557