caa a22 4500 606158316 CHVBK 20210128100618.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10557-015-6631-4 doi (NATIONALLICENCE)springer-10.1007/s10557-015-6631-4 Impact of Intracoronary Adenosine on Myonecrosis in Patients with Unstable Angina Pectoris Undergoing Percutaneous Coronary Intervention [Elektronische Daten] [Filiz Kizilirmak, Haci Gunes, Gultekin Demir, Tayyar Gokdeniz, Ekrem Guler, Beytullah Cakal, Mehmet Omaygenç, Fatih Yılmaz, Umeyir Savur, Irfan Barutcu] Background: In this study, we aimed to investigate the impact of prophylactic intracoronary adenosine administered during percutaneous coronary intervention (PCI) due to unstable angina pectoris on myonecrosis by measuring post-procedural levels of cardiac troponin I (cTnI) and creatine kinase-myocardial band (CK-MB). Methods: A total of 122 patients with unstable angina undergoing PCI were included in this single-center, double-blind, randomized study. The patients were randomly allocated to adenosine and placebo groups. In the adenosine group, a single-dose of intracoronary adenosine (100μg for the right coronary artery and 150μg for the left coronary artery) was administered. Primary endpoint was post-PCI myonecrosis, which was defined as abnormal levels of periprocedural cTnI. Secondary endpoints were defined as elevated cTnI levels [5 × upper limit of normal (ULN)], abnormal CK-MB levels, angiographic coronary flow measured by Thrombolysis In Myocardial Infarction (TIMI) frame count (TFC), the cumulative incidence of in-hospital death and in-hospital urgent target vessel revascularization (TVR). Results: Clinical and angiographic characteristics of both adenosine (61 patients, 61±9years) and placebo (61 patients, 59±10years) groups were similar (p>0.05 for all). Post-procedural abnormal cTnI levels in the adenosine group were significantly lower than the placebo group (32% vs. 55%, p: 0.011). cTnI >5 × ULN (21% vs. 31%, p: 0.217) and abnormal CK-MB levels (11% vs. 19%, p: 0.263) were similar in both groups. Post-procedural TFCs in the adenosine group were significantly lower than the placebo group (24±4 vs. 27±5, p: 0.004). In-hospital events including death and urgent TVR were not observed in either group. Conclusion: Intracoronary administration of single-dose adenosine in patients with unstable angina undergoing PCI is associated with decreased periprocedural myonecrosis and improved coronary blood flow. Springer Science+Business Media New York, 2015 Myonecrosis nationallicence Adenosine nationallicence Percutaneous coronary intervention nationallicence Unstable angina nationallicence Kizilirmak Filiz Faculty of Medicine, Cardiology Department, Medipol University Hospital, TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar, 34214, İstanbul, Turkey aut Gunes Haci Faculty of Medicine, Cardiology Department, Medipol University Hospital, TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar, 34214, İstanbul, Turkey aut Demir Gultekin Faculty of Medicine, Cardiology Department, Medipol University Hospital, TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar, 34214, İstanbul, Turkey aut Gokdeniz Tayyar Faculty of Medicine, Cardiology Department, Medipol University Hospital, TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar, 34214, İstanbul, Turkey aut Guler Ekrem Faculty of Medicine, Cardiology Department, Medipol University Hospital, TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar, 34214, İstanbul, Turkey aut Cakal Beytullah Faculty of Medicine, Cardiology Department, Medipol University Hospital, TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar, 34214, İstanbul, Turkey aut Omaygenç Mehmet Faculty of Medicine, Cardiology Department, Medipol University Hospital, TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar, 34214, İstanbul, Turkey aut Yılmaz Fatih Kartal Kosuyolu Research and Education Hospital, Istanbul University, Istanbul, Turkey aut Savur Umeyir Faculty of Medicine, Cardiology Department, Medipol University Hospital, TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar, 34214, İstanbul, Turkey aut Barutcu Irfan Faculty of Medicine, Cardiology Department, Medipol University Hospital, TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar, 34214, İstanbul, Turkey aut Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/6(2015-12-01), 519-526 0920-3206 29:6<519 2015 29 10557 https://doi.org/10.1007/s10557-015-6631-4 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10557-015-6631-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kizilirmak Filiz Faculty of Medicine, Cardiology Department, Medipol University Hospital, TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar, 34214, İstanbul, Turkey aut NATIONALLICENCE 700 1- Gunes Haci Faculty of Medicine, Cardiology Department, Medipol University Hospital, TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar, 34214, İstanbul, Turkey aut NATIONALLICENCE 700 1- Demir Gultekin Faculty of Medicine, Cardiology Department, Medipol University Hospital, TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar, 34214, İstanbul, Turkey aut NATIONALLICENCE 700 1- Gokdeniz Tayyar Faculty of Medicine, Cardiology Department, Medipol University Hospital, TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar, 34214, İstanbul, Turkey aut NATIONALLICENCE 700 1- Guler Ekrem Faculty of Medicine, Cardiology Department, Medipol University Hospital, TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar, 34214, İstanbul, Turkey aut NATIONALLICENCE 700 1- Cakal Beytullah Faculty of Medicine, Cardiology Department, Medipol University Hospital, TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar, 34214, İstanbul, Turkey aut NATIONALLICENCE 700 1- Omaygenç Mehmet Faculty of Medicine, Cardiology Department, Medipol University Hospital, TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar, 34214, İstanbul, Turkey aut NATIONALLICENCE 700 1- Yılmaz Fatih Kartal Kosuyolu Research and Education Hospital, Istanbul University, Istanbul, Turkey aut NATIONALLICENCE 700 1- Savur Umeyir Faculty of Medicine, Cardiology Department, Medipol University Hospital, TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar, 34214, İstanbul, Turkey aut NATIONALLICENCE 700 1- Barutcu Irfan Faculty of Medicine, Cardiology Department, Medipol University Hospital, TEM Avrupa Otoyolu Göztepe Çıkışı No: 1 Bağcılar, 34214, İstanbul, Turkey aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/6(2015-12-01), 519-526 0920-3206 29:6<519 2015 29 10557