caa a22 4500 606158324 CHVBK 20210128100618.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10557-015-6628-z doi (NATIONALLICENCE)springer-10.1007/s10557-015-6628-z The Impact of Peripheral Nerve Stimulation on Coronary Blood Flow and Endothelial Function [Elektronische Daten] [Anthony Camuglia, Mistre Alemayehu, Andrew McLellan, Sabrina Wall, Nour Abu-Romeh, Shahar Lavi] Purpose: The geko™ device is a small transcutaneous nerve stimulator that is applied non-invasively to the skin over the common peroneal nerve to stimulate peripheral blood flow. The purpose of this study was to investigate the effect of peripheral nerve stimulation on coronary flow dynamics and systemic endothelial function. Methods: We enrolled 10 male patients, age 59±11years, with symptomatic obstructive coronary disease undergoing percutaneous coronary intervention (PCI). Coronary flow dynamics were assessed invasively using Doppler flow wire at baseline and with nerve stimulation for 4min. Measurements were taken in the stenotic coronary artery and in a control vessel without obstructive disease. At a separate visit, peripheral blood flow at the popliteal artery (using duplex ultrasound assessment) and endothelial function assessed by peripheral artery tonometry (PAT) were measured at baseline and after one hour of nerve stimulation. Results: Compared to baseline, there was a significant increase in coronary blood flow as measured by average peak velocity (APV) in the control vessel with nerve stimulation (20.3±7.7 to 23.5±10cm/s; p=0.03) and non-significant increase in the stenotic vessel (21.9±12 to 23.9±12.9cm/s; p=0.23). Coronary flow reserve did not change significantly. Reactive hyperemia-peripheral arterial tonometry (Rh-PAT) increased from 2.28±0.39 to 2.67±0.6, p=0.045. Conclusions: A few minutes of peripheral nerve stimulation may improve coronary blood flow. This effect is more prominent in non-stenotic vessels. Longer stimulation improved endothelial function. Springer Science+Business Media New York, 2015 Angina nationallicence Endothelium nationallicence Blood flow nationallicence Coronary artery disease nationallicence Electrical stimulation nationallicence Camuglia Anthony London Health Sciences Centre, 339 Windermere Road, PO Box 5339, London, ON N6A 5A5, Canada aut Alemayehu Mistre London Health Sciences Centre, 339 Windermere Road, PO Box 5339, London, ON N6A 5A5, Canada aut McLellan Andrew London Health Sciences Centre, 339 Windermere Road, PO Box 5339, London, ON N6A 5A5, Canada aut Wall Sabrina London Health Sciences Centre, 339 Windermere Road, PO Box 5339, London, ON N6A 5A5, Canada aut Abu-Romeh Nour London Health Sciences Centre, 339 Windermere Road, PO Box 5339, London, ON N6A 5A5, Canada aut Lavi Shahar London Health Sciences Centre, 339 Windermere Road, PO Box 5339, London, ON N6A 5A5, Canada aut Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/6(2015-12-01), 527-533 0920-3206 29:6<527 2015 29 10557 https://doi.org/10.1007/s10557-015-6628-z text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10557-015-6628-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Camuglia Anthony London Health Sciences Centre, 339 Windermere Road, PO Box 5339, London, ON N6A 5A5, Canada aut NATIONALLICENCE 700 1- Alemayehu Mistre London Health Sciences Centre, 339 Windermere Road, PO Box 5339, London, ON N6A 5A5, Canada aut NATIONALLICENCE 700 1- McLellan Andrew London Health Sciences Centre, 339 Windermere Road, PO Box 5339, London, ON N6A 5A5, Canada aut NATIONALLICENCE 700 1- Wall Sabrina London Health Sciences Centre, 339 Windermere Road, PO Box 5339, London, ON N6A 5A5, Canada aut NATIONALLICENCE 700 1- Abu-Romeh Nour London Health Sciences Centre, 339 Windermere Road, PO Box 5339, London, ON N6A 5A5, Canada aut NATIONALLICENCE 700 1- Lavi Shahar London Health Sciences Centre, 339 Windermere Road, PO Box 5339, London, ON N6A 5A5, Canada aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/6(2015-12-01), 527-533 0920-3206 29:6<527 2015 29 10557