caa a22 4500 606158367 CHVBK 20210128100619.0 cr unu---uuuuu 210128e20151201xx s 000 0 eng 10.1007/s10557-015-6621-6 doi (NATIONALLICENCE)springer-10.1007/s10557-015-6621-6 From Protecting the Heart to Improving Athletic Performance - the Benefits of Local and Remote Ischaemic Preconditioning [Elektronische Daten] [Vikram Sharma, Reuben Marsh, Brian Cunniffe, Marco Cardinale, Derek Yellon, Sean Davidson] Remote Ischemic Preconditioning (RIPC) is a non-invasive cardioprotective intervention that involves brief cycles of limb ischemia and reperfusion. This is typically delivered by inflating and deflating a blood pressure cuff on one or more limb(s) for several cycles, each inflation-deflation being 3-5min in duration. RIPC has shown potential for protecting the heart and other organs from injury due to lethal ischemia and reperfusion injury, in a variety of clinical settings. The mechanisms underlying RIPC are under intense investigation but are just beginning to be deciphered. Emerging evidence suggests that RIPC has the potential to improve exercise performance, via both local and remote mechanisms. This review discusses the clinical studies that have investigated the role of RIPC in cardioprotection as well as those studying its applicability in improving athletic performance, while examining the potential mechanisms involved. The Author(s), 2015 Remote ischemic preconditioning nationallicence Exercise performance nationallicence Sports nationallicence Cardioprotection nationallicence Ischemia-reperfusion injury nationallicence CABG nationallicence PCI nationallicence Perconditioning nationallicence Postconditioning nationallicence Acute kidney injury nationallicence AAR : Area at risk nationallicence AKI : Acute kidney injury nationallicence AKT : Term used for protein kinase B nationallicence AT 1 receptor : Angiotensin II receptor type 1 nationallicence ATP : Adenosine triphosphate nationallicence AUC : Area under the curve nationallicence BP : Blood pressure nationallicence CABG : Coronary artery bypass grafting nationallicence CGRP : Calcitonin gene-related peptide nationallicence CK-MB : Creatine kinase-myocardial band nationallicence CRISP stent : Cardiac remote ischemic preconditioning in coronary stenting nationallicence cTnI : Cardiac troponin I nationallicence cTnT : Cardiac troponin I nationallicence CXCR4 : Chemokine receptor type 4 nationallicence ERICCA : Effect of remote ischaemic preconditioning on clinical outcomes in patients undergoing coronary artery bypass graft surgery nationallicence ERIC-LYSIS : Effect of remote ischemic conditioning in heart attack patients nationallicence hs-cTnI : High-sensitivity cardiac troponin I nationallicence IPC : Ischemic preconditioning nationallicence IR : Ischemia and reperfusion nationallicence KATP channels : ATP-sensitive potassium channels nationallicence kDa : Kilodaltons nationallicence MACE : Major adverse cardiac events nationallicence MACCE : Major adverse cardiac and cerebrovascular event nationallicence MERIT : Myocardial event reduction with ischemic preconditioning therapy nationallicence MI : Myocardial infarction nationallicence miRNA : micro- ribonucleic acid nationallicence mPTP : Mitochondrial permeability transition pore nationallicence MRI : Magnetic resonance imaging nationallicence NSTEMI : Non-ST elevation myocardial infarction nationallicence PCI : Percutaneous coronary intervention nationallicence PI3K : Phosphatidylinositol-3-OH kinase nationallicence PKC : Protein kinase C nationallicence pPCI : Primary percutaneous coronary intervention nationallicence RIPC : Remote ischemic preconditioning nationallicence RIPercon : Remote ischemic perconditioning nationallicence RIPostC : Remote ischemic post conditioning nationallicence RIPOST-MI : Remote ischemic post-conditioning in myocardial infarction nationallicence RISK : Reperfusion injury salvage kinase nationallicence SAFE : Survivor activating factor enhancement nationallicence SDF = 1 α : Stromal cell-derived factor 1 nationallicence STAT : Signal transducer and activator of transcription nationallicence STEMI : ST elevation myocardial infarction nationallicence Sharma Vikram Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA aut Marsh Reuben The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, WC1E 6HX, London, UK aut Cunniffe Brian English institute of Sport, Bisham, Marlow, UK aut Cardinale Marco Institute of Sport, Exercise and Health, UCL, London, UK aut Yellon Derek The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, WC1E 6HX, London, UK aut Davidson Sean The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, WC1E 6HX, London, UK aut Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/6(2015-12-01), 573-588 0920-3206 29:6<573 2015 29 10557 https://doi.org/10.1007/s10557-015-6621-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10557-015-6621-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sharma Vikram Department of Internal Medicine, Cleveland Clinic, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Marsh Reuben The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, WC1E 6HX, London, UK aut NATIONALLICENCE 700 1- Cunniffe Brian English institute of Sport, Bisham, Marlow, UK aut NATIONALLICENCE 700 1- Cardinale Marco Institute of Sport, Exercise and Health, UCL, London, UK aut NATIONALLICENCE 700 1- Yellon Derek The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, WC1E 6HX, London, UK aut NATIONALLICENCE 700 1- Davidson Sean The Hatter Cardiovascular Institute, University College London, 67 Chenies Mews, WC1E 6HX, London, UK aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/6(2015-12-01), 573-588 0920-3206 29:6<573 2015 29 10557