caa a22 4500 606158545 CHVBK 20210128100620.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10557-015-6596-3 doi (NATIONALLICENCE)springer-10.1007/s10557-015-6596-3 Gender-Related Differences in Atherosclerosis [Elektronische Daten] [Pankaj Mathur, Bohuslav Ostadal, Francesco Romeo, Jawahar Mehta] Atherosclerotic cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. Considerable research has been done over the last several decades to understand the pathophysiology of atherosclerosis. It is widely believed that estrogen is responsible for the protection of women from CVD in the premenopausal age group. However, hormone replacement therapy has failed to decrease CVD events in clinical studies which points to the complexity of the relationship between vascular biology and estrogen hormones. Interestingly, preponderance of vascular and connective tissue disorders in women also points to aninherent role of hormones and tissue factors in maintenance of vascular endothelial function. The differential effect of GPER, lipoprotein A, TLRs, leucocyte-platelet aggregate markers in men and women also suggests inherent gender-relateddifferences in thepathophysiology of atherosclerosis. A better understanding of the pathophysiology is likely to open ways to improve evidence-based treatment of CVD in women. Springer Science+Business Media New York, 2015 Atherosclerosis nationallicence Gender nationallicence Mathur Pankaj Cardiovascular Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, 4301 West Markham St., 72205, Little Rock, AR, USA aut Ostadal Bohuslav Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic aut Romeo Francesco University of Rome "Tor Vergata”, Rome, Italy aut Mehta Jawahar Cardiovascular Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, 4301 West Markham St., 72205, Little Rock, AR, USA aut Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/4(2015-08-01), 319-327 0920-3206 29:4<319 2015 29 10557 https://doi.org/10.1007/s10557-015-6596-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10557-015-6596-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mathur Pankaj Cardiovascular Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, 4301 West Markham St., 72205, Little Rock, AR, USA aut NATIONALLICENCE 700 1- Ostadal Bohuslav Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic aut NATIONALLICENCE 700 1- Romeo Francesco University of Rome "Tor Vergata”, Rome, Italy aut NATIONALLICENCE 700 1- Mehta Jawahar Cardiovascular Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, 4301 West Markham St., 72205, Little Rock, AR, USA aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/4(2015-08-01), 319-327 0920-3206 29:4<319 2015 29 10557