caa a22 4500 606158561 CHVBK 20210128100620.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10557-015-6603-8 doi (NATIONALLICENCE)springer-10.1007/s10557-015-6603-8 The Role of 17β-Estradiol in Myocardial Hypertrophy in Females in the Presence and Absence of Hypertension [Elektronische Daten] [Carin Wittnich, Jack Wallen, Michael Belanger] Purpose: There are gender-differences in the development of cardiac hypertrophy, which appear to be related, in part, to sex hormones. This report gives an overview of this relationship and reports on original data assessing how varying levels of plasma 17β-estradiol determine relative heart size, in vivo function, in hypertensive versus normotensive rats. Methods: Female spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats were either surgically neutered or sham operated at 21days of age. A subgroup of neutered females received 17β-estradiol replacement. At 6months, in vivo heart function was measured, the heart/body weight ratio (mg/g) was assessed as a measure of hypertrophy and correlated with plasma 17β-estradiol. Results: There was a significant positive relationship between plasma 17β-estradiol and heart/body weight ratio in both WKY (R = 0.509, P = 0.011) and SHR females (R = 0.359, P = 0.032). Interestingly, the slope of this relationship was 2-fold steeper in the WKY females, suggesting a blunted effect in the SHR, whose hearts also had 35 % lower ERβ content. With increasing plasma estradiol levels, WKY females showed improved LV function while SHR females showed impaired LV relaxation. Conclusions: Plasma estradiol modulates relative heart mass in both normotensive and hypertensive female rats. With any increase in plasma 17β-estradiol, hypertensive females show a blunted response compared with the normotensive females, which may be related to a reduced estrogen receptor expression in the presence of hypertension. In contrast to normotensive females, hypertensive females showed impaired function with increases in plasma 17β-estradiol. Springer Science+Business Media New York, 2015 17β-estradiol nationallicence Myocardium nationallicence Estrogen receptor nationallicence Hypertrophy nationallicence Hypertension nationallicence Wittnich Carin From the Departments of Physiology (J.W., C.W., M.B) and Surgery (C.W.) and The Cardiovascular Sciences Collaborative Program (W.J.W., C.W.), University of Toronto, 1 King's College Circle, Medical Sciences Bldg. Room 7256, M5S 1A8, Toronto, Ontario, Canada aut Wallen Jack From the Departments of Physiology (J.W., C.W., M.B) and Surgery (C.W.) and The Cardiovascular Sciences Collaborative Program (W.J.W., C.W.), University of Toronto, 1 King's College Circle, Medical Sciences Bldg. Room 7256, M5S 1A8, Toronto, Ontario, Canada aut Belanger Michael From the Departments of Physiology (J.W., C.W., M.B) and Surgery (C.W.) and The Cardiovascular Sciences Collaborative Program (W.J.W., C.W.), University of Toronto, 1 King's College Circle, Medical Sciences Bldg. Room 7256, M5S 1A8, Toronto, Ontario, Canada aut Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/4(2015-08-01), 347-353 0920-3206 29:4<347 2015 29 10557 https://doi.org/10.1007/s10557-015-6603-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10557-015-6603-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wittnich Carin From the Departments of Physiology (J.W., C.W., M.B) and Surgery (C.W.) and The Cardiovascular Sciences Collaborative Program (W.J.W., C.W.), University of Toronto, 1 King's College Circle, Medical Sciences Bldg. Room 7256, M5S 1A8, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Wallen Jack From the Departments of Physiology (J.W., C.W., M.B) and Surgery (C.W.) and The Cardiovascular Sciences Collaborative Program (W.J.W., C.W.), University of Toronto, 1 King's College Circle, Medical Sciences Bldg. Room 7256, M5S 1A8, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Belanger Michael From the Departments of Physiology (J.W., C.W., M.B) and Surgery (C.W.) and The Cardiovascular Sciences Collaborative Program (W.J.W., C.W.), University of Toronto, 1 King's College Circle, Medical Sciences Bldg. Room 7256, M5S 1A8, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/4(2015-08-01), 347-353 0920-3206 29:4<347 2015 29 10557