caa a22 4500 606158588 CHVBK 20210128100620.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s10557-015-6594-5 doi (NATIONALLICENCE)springer-10.1007/s10557-015-6594-5 Unique Aspects of Coronary Artery Disease in Indian Women [Elektronische Daten] [Parloop Bhatt, Parth Parikh, Aditi Patel, Roosha Parikh, Apurva Patel, Jawahar Mehta, Keyur Parikh] Purpose: Epidemiologic and clinical research suggests important gender-related differences in the prevalence, presentation, associated conventional and non-conventional risk factors, management and outcomes of coronary heart disease (CHD) patients. Adequate data is not available for Indian population where prevalence of CHD and depression is high. Method: We conducted an observational, single-center, study from January 2010 to December 2011 on 10450 consecutive patients visiting a tertiary care center, Ahmedabad, Gujarat, India who presented with complaints related to CHD. Results: Of these, 6867 patients had coronary artery disease (CAD) as confirmed by angiographic investigation; 5678 were males, and 1189 were females with similar mean age. As compared to males, females had higher prevalence of hypertension, diabetes and obesity while males had higher prevalence of smoking. Invasive treatment options like Coronary Artery Bypass Grafting (p < 0.001) and Percutaneous Coronary Intervention (p = 0.001) were used less often to treat females, and medical therapy (p < 0.001) was the preferred treatment option irrespective of the contributing risk factors/extent of CAD. Depression was observed in 39.8% of acute coronary syndrome patients (n = 1648) as assessed by MARDS scale. It was higher in female patients and in low socioeconomic strata (p < 0.001).At 12 and 36months, rates of revascularization (p < 0.001) and mortality (p < 0.005) were higher with poor quality of life (QoL) (P < 0.001) in depressed CAD patients. Conclusion: In India, women appear to have a higher prevalence of hypertension, diabetes, obesity, and family history of CHD. Yet women get invasive treatments less often than men. Depression is also more common in women and is associated with poor QoL and early mortality than men. Springer Science+Business Media New York, 2015 Coronary artery disease nationallicence Depression nationallicence Gender difference nationallicence Clinical outcomes nationallicence Quality of life nationallicence Bhatt Parloop Department of Pharmacology, L. M. College of Pharmacy, Navrangpura, 380060, Ahmedabad, Gujarat, India aut Parikh Parth Care Institute of Medical Sciences, Ahmedabad, India aut Patel Aditi Care Institute of Medical Sciences, Ahmedabad, India aut Parikh Roosha Cleveland Clinic, Cleveland, OH, USA aut Patel Apurva Cleveland Clinic, Cleveland, OH, USA aut Mehta Jawahar University of Arkansas for Medical Sciences, Little Rock, AR, USA aut Parikh Keyur Care Institute of Medical Sciences, Ahmedabad, India aut Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/4(2015-08-01), 369-376 0920-3206 29:4<369 2015 29 10557 https://doi.org/10.1007/s10557-015-6594-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10557-015-6594-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bhatt Parloop Department of Pharmacology, L. M. College of Pharmacy, Navrangpura, 380060, Ahmedabad, Gujarat, India aut NATIONALLICENCE 700 1- Parikh Parth Care Institute of Medical Sciences, Ahmedabad, India aut NATIONALLICENCE 700 1- Patel Aditi Care Institute of Medical Sciences, Ahmedabad, India aut NATIONALLICENCE 700 1- Parikh Roosha Cleveland Clinic, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Patel Apurva Cleveland Clinic, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Mehta Jawahar University of Arkansas for Medical Sciences, Little Rock, AR, USA aut NATIONALLICENCE 700 1- Parikh Keyur Care Institute of Medical Sciences, Ahmedabad, India aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/4(2015-08-01), 369-376 0920-3206 29:4<369 2015 29 10557