caa a22 4500 606158685 CHVBK 20210128100621.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10557-015-6604-7 doi (NATIONALLICENCE)springer-10.1007/s10557-015-6604-7 Nifekalant Versus Amiodarone in the Treatment of Cardiac Arrest: an Experimental Study in a Swine Model of Prolonged Ventricular Fibrillation [Elektronische Daten] [George Karlis, Nicoletta Iacovidou, Pavlos Lelovas, Panagiota Niforopoulou, Apostolos Papalois, Ioanna Siafaka, Spyros Mentzelopoulos, Theodoros Xanthos] Purpose: The purpose of the experiment was to compare the effects of nifekalant and amiodarone on the return of spontaneous circulation (ROSC), survival, as well as on the hemodynamic parameters in a swine model of prolonged ventricular fibrillation (VF). Methods: After 8min of untreated VF, bolus doses of epinephrine (adrenaline) and either nifekalant, or amiodarone, or saline (n = 10 per group), were administered after randomization. Cardiopulmonary resuscitation (CPR) was commenced immediately after drug administration and defibrillation was attempted 2min later. CPR was resumed for another 2min after each defibrillation attempt and the same dose of adrenaline was given every 4th minute during CPR. Results: Forty-eight hour survival was significantly higher with nifekalant compared to amiodarone (p < 0.001) and saline (p = 0.02), (9/10 vs. 0/10 vs. 3/10, respectively). Systolic aortic pressure, diastolic aortic pressure and coronary perfusion pressure were significantly higher with nifekalant during CPR and immediate post-resuscitation period (p < 0.05). The animals in the amiodarone group had a slower heart rate at the 1st and 45th min post-ROSC (p < 0.001 and p = 0.006, respectively). The number of electric shocks required for terminating VF, time to ROSC and adrenaline dose were significantly higher with amiodarone compared to nifekalant (p < 0.001). Conclusions: Nifekalant showed a more favorable hemodynamic profile and improved survival compared to amiodarone and saline in this swine model. Springer Science+Business Media New York, 2015 Arrhythmia nationallicence Cardiopulmonary resuscitation nationallicence Antiarrhythmic drug nationallicence Cardiac arrest nationallicence Nifekalant nationallicence Amiodarone nationallicence Karlis George 2nd Department of Internal Medicine, Sismanoglio General Hospital, Athens, Greece aut Iacovidou Nicoletta Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece aut Lelovas Pavlos Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece aut Niforopoulou Panagiota Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece aut Papalois Apostolos Experimental-Research Center ELPEN Pharmaceutical, Athens, Greece aut Siafaka Ioanna 1st Anesthesiology Clinic, Pain Relief and Palliative Care Unit, Aretaieio Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece aut Mentzelopoulos Spyros 1st Department of Intensive Care Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece aut Xanthos Theodoros Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece aut Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/5(2015-10-01), 425-431 0920-3206 29:5<425 2015 29 10557 https://doi.org/10.1007/s10557-015-6604-7 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10557-015-6604-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Karlis George 2nd Department of Internal Medicine, Sismanoglio General Hospital, Athens, Greece aut NATIONALLICENCE 700 1- Iacovidou Nicoletta Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece aut NATIONALLICENCE 700 1- Lelovas Pavlos Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece aut NATIONALLICENCE 700 1- Niforopoulou Panagiota Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece aut NATIONALLICENCE 700 1- Papalois Apostolos Experimental-Research Center ELPEN Pharmaceutical, Athens, Greece aut NATIONALLICENCE 700 1- Siafaka Ioanna 1st Anesthesiology Clinic, Pain Relief and Palliative Care Unit, Aretaieio Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece aut NATIONALLICENCE 700 1- Mentzelopoulos Spyros 1st Department of Intensive Care Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece aut NATIONALLICENCE 700 1- Xanthos Theodoros Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/5(2015-10-01), 425-431 0920-3206 29:5<425 2015 29 10557