caa a22 4500 606158790 CHVBK 20210128100621.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10557-015-6580-y doi (NATIONALLICENCE)springer-10.1007/s10557-015-6580-y Central and Peripheral Irisin Differentially Regulate Blood Pressure [Elektronische Daten] [Weizhen Zhang, Lin Chang, Chao Zhang, Ruthann Zhang, Ziru Li, Biaoxin Chai, Jiyao Li, Eugene Chen, Michael Mulholland] Introduction: Irisin is a newly identified 112 amino acid hormone, derived as a product of fibronectin type III domain containing 5 (FNDC5), which is highly related to metabolic activity in skeletal muscle and brown fat. The effects of irisin on cardiovascular functions are unknown. Purpose: To explore the effects of central and peripheral irisin on cardiovascular functions. Methods: Irisin was either administrated into 3rd ventricle of rats or intravenously, and its effects on blood pressure and cardiac contractibility measured. Results: Administration of recombinant human irisin into the 3rd brain ventricle of rats activated neurons in the paraventricular nuclei of the hypothalamus. Central administration of irisin increased blood pressure and cardiac contractibility. Exogenous irisin reversed atenolol-induced inhibition of cardiac contractibility. In contrast, peripheral administration of irisin reduced blood pressure in both control and spontaneously hypertensive rats. Irisin dilated mesenteric artery rings through ATP-sensitive potassium channels. Conclusion: Our studies indicate that central and peripheral irisin may differentially regulate cardiovascular activities. Springer Science+Business Media New York, 2015 Irisin nationallicence Hypothalamus nationallicence Blood pressure nationallicence Cardiac contractibility nationallicence Zhang Weizhen Department of Surgery, University of Michigan, 4618B, MS II, 1301 E. Catherine Street, 48109, Ann Arbor, MI, USA aut Chang Lin Department of Internal Medicine, University of Michigan, 2800 Plymouth Rd, 48109, Ann Arbor, MI, USA aut Zhang Chao Department of Surgery, University of Michigan, 4618B, MS II, 1301 E. Catherine Street, 48109, Ann Arbor, MI, USA aut Zhang Ruthann Department of Internal Medicine, University of Michigan, 2800 Plymouth Rd, 48109, Ann Arbor, MI, USA aut Li Ziru Department of Surgery, University of Michigan, 4618B, MS II, 1301 E. Catherine Street, 48109, Ann Arbor, MI, USA aut Chai Biaoxin Department of Surgery, University of Michigan, 4618B, MS II, 1301 E. Catherine Street, 48109, Ann Arbor, MI, USA aut Li Jiyao Department of Surgery, University of Michigan, 4618B, MS II, 1301 E. Catherine Street, 48109, Ann Arbor, MI, USA aut Chen Eugene Department of Internal Medicine, University of Michigan, 2800 Plymouth Rd, 48109, Ann Arbor, MI, USA aut Mulholland Michael Department of Surgery, University of Michigan, 4618B, MS II, 1301 E. Catherine Street, 48109, Ann Arbor, MI, USA aut Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/2(2015-04-01), 121-127 0920-3206 29:2<121 2015 29 10557 https://doi.org/10.1007/s10557-015-6580-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10557-015-6580-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhang Weizhen Department of Surgery, University of Michigan, 4618B, MS II, 1301 E. Catherine Street, 48109, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Chang Lin Department of Internal Medicine, University of Michigan, 2800 Plymouth Rd, 48109, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Zhang Chao Department of Surgery, University of Michigan, 4618B, MS II, 1301 E. Catherine Street, 48109, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Zhang Ruthann Department of Internal Medicine, University of Michigan, 2800 Plymouth Rd, 48109, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Li Ziru Department of Surgery, University of Michigan, 4618B, MS II, 1301 E. Catherine Street, 48109, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Chai Biaoxin Department of Surgery, University of Michigan, 4618B, MS II, 1301 E. Catherine Street, 48109, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Li Jiyao Department of Surgery, University of Michigan, 4618B, MS II, 1301 E. Catherine Street, 48109, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Chen Eugene Department of Internal Medicine, University of Michigan, 2800 Plymouth Rd, 48109, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Mulholland Michael Department of Surgery, University of Michigan, 4618B, MS II, 1301 E. Catherine Street, 48109, Ann Arbor, MI, USA aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/2(2015-04-01), 121-127 0920-3206 29:2<121 2015 29 10557