caa a22 4500 606158804 CHVBK 20210128100621.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10557-015-6581-x doi (NATIONALLICENCE)springer-10.1007/s10557-015-6581-x Cardioprotection by Curcumin Post-Treatment in Rats with Established Chronic Kidney Disease [Elektronische Daten] [Sauri Hernández-Reséndiz, Francisco Correa, Wylly García-Niño, Mabel Buelna-Chontal, Francisco Roldán, Ixchel Ramírez-Camacho, Carolina Delgado-Toral, Roxana Carbó, José Pedraza-Chaverrí, Edilia Tapia, Cecilia Zazueta] Purpose: The pathogenic mechanisms leading to cardiovascular disorders in patients with chronic kidney disease have not been clearly established, although increased oxidative stress has been pointed out as a potential cause. Therefore, as cardiovascular events are still the first cause of death in patients with chronic kidney disease and traditional drugs or therapies rarely have effects on cardiac complications, we sought to determine the effect of curcumin in treating cardiac dysfunction in rats with established chronic renal disease. Methods and Results: Treatment consisted in daily administration of curcumin (120mg/kg/day) dissolved in 0.05% carboxymethylcellulose via oral gavages during 30days, beginning from day 30 after 5/6 nephrectomy (5/6Nx). Cardiac function, markers of oxidative stress, activation of PI3K/Akt/GSK3β and MEK1/2-ERK1/2 pathway, metalloproteinase-II (MMP-2) content, overall gelatinolytic activity, ROS production and mitochondrial integrity were evaluated after 1-month treatment. Curcumin restored systolic blood pressure, diminished interventricular and rear wall thickening, decreased left ventricle dimension at end-systole (LVSd) and restored ejection fraction in nephrectomized rats. Also, it diminished metalloproteinase-II levels and overall gelatinase activity, decreased oxidative stress and inhibited the mitochondrial permeability transition pore opening. Conclusion: Our findings suggest that curcumin might have therapeutic potential in treatment of heart disease in patients with established CKD by attenuating oxidative stress-related events as cardiac remodeling, mitochondrial dysfunction and cell death. Springer Science+Business Media New York, 2015 Curcumin nationallicence Heart remodeling nationallicence MAPK signaling nationallicence Mitochondrial function nationallicence Oxidative stress nationallicence Hernández-Reséndiz Sauri Department of Cardiovascular Biomedicine, National Institute of Cardiology I. Ch, Juan Badiano No. 1. Colonia Sección XVI, 14080, México, DF, Mexico aut Correa Francisco Department of Cardiovascular Biomedicine, National Institute of Cardiology I. Ch, Juan Badiano No. 1. Colonia Sección XVI, 14080, México, DF, Mexico aut García-Niño Wylly Department of Cardiovascular Biomedicine, National Institute of Cardiology I. Ch, Juan Badiano No. 1. Colonia Sección XVI, 14080, México, DF, Mexico aut Buelna-Chontal Mabel Department of Cardiovascular Biomedicine, National Institute of Cardiology I. Ch, Juan Badiano No. 1. Colonia Sección XVI, 14080, México, DF, Mexico aut Roldán Francisco Department of Echocardiography, National Institute of Cardiology I. Ch, 14080, Mexico City, Mexico aut Ramírez-Camacho Ixchel Department of Cardiovascular Biomedicine, National Institute of Cardiology I. Ch, Juan Badiano No. 1. Colonia Sección XVI, 14080, México, DF, Mexico aut Delgado-Toral Carolina Department of Biology, Faculty of Chemistry, UNAM, Mexico City, Mexico aut Carbó Roxana Department of Cardiovascular Biomedicine, National Institute of Cardiology I. Ch, Juan Badiano No. 1. Colonia Sección XVI, 14080, México, DF, Mexico aut Pedraza-Chaverrí José Department of Biology, Faculty of Chemistry, UNAM, Mexico City, Mexico aut Tapia Edilia Renal Pathophysiology Laboratory, Department of Nephrology, National Institute of Cardiology I. Ch, 14080, Mexico City, Mexico aut Zazueta Cecilia Department of Cardiovascular Biomedicine, National Institute of Cardiology I. Ch, Juan Badiano No. 1. Colonia Sección XVI, 14080, México, DF, Mexico aut Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/2(2015-04-01), 111-120 0920-3206 29:2<111 2015 29 10557 https://doi.org/10.1007/s10557-015-6581-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10557-015-6581-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hernández-Reséndiz Sauri Department of Cardiovascular Biomedicine, National Institute of Cardiology I. Ch, Juan Badiano No. 1. Colonia Sección XVI, 14080, México, DF, Mexico aut NATIONALLICENCE 700 1- Correa Francisco Department of Cardiovascular Biomedicine, National Institute of Cardiology I. Ch, Juan Badiano No. 1. Colonia Sección XVI, 14080, México, DF, Mexico aut NATIONALLICENCE 700 1- García-Niño Wylly Department of Cardiovascular Biomedicine, National Institute of Cardiology I. Ch, Juan Badiano No. 1. Colonia Sección XVI, 14080, México, DF, Mexico aut NATIONALLICENCE 700 1- Buelna-Chontal Mabel Department of Cardiovascular Biomedicine, National Institute of Cardiology I. Ch, Juan Badiano No. 1. Colonia Sección XVI, 14080, México, DF, Mexico aut NATIONALLICENCE 700 1- Roldán Francisco Department of Echocardiography, National Institute of Cardiology I. Ch, 14080, Mexico City, Mexico aut NATIONALLICENCE 700 1- Ramírez-Camacho Ixchel Department of Cardiovascular Biomedicine, National Institute of Cardiology I. Ch, Juan Badiano No. 1. Colonia Sección XVI, 14080, México, DF, Mexico aut NATIONALLICENCE 700 1- Delgado-Toral Carolina Department of Biology, Faculty of Chemistry, UNAM, Mexico City, Mexico aut NATIONALLICENCE 700 1- Carbó Roxana Department of Cardiovascular Biomedicine, National Institute of Cardiology I. Ch, Juan Badiano No. 1. Colonia Sección XVI, 14080, México, DF, Mexico aut NATIONALLICENCE 700 1- Pedraza-Chaverrí José Department of Biology, Faculty of Chemistry, UNAM, Mexico City, Mexico aut NATIONALLICENCE 700 1- Tapia Edilia Renal Pathophysiology Laboratory, Department of Nephrology, National Institute of Cardiology I. Ch, 14080, Mexico City, Mexico aut NATIONALLICENCE 700 1- Zazueta Cecilia Department of Cardiovascular Biomedicine, National Institute of Cardiology I. Ch, Juan Badiano No. 1. Colonia Sección XVI, 14080, México, DF, Mexico aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/2(2015-04-01), 111-120 0920-3206 29:2<111 2015 29 10557