caa a22 4500 606158820 CHVBK 20210128100621.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10557-015-6583-8 doi (NATIONALLICENCE)springer-10.1007/s10557-015-6583-8 Pharmacotherapy and Other Therapeutic Modalities for Managing Arrhythmogenic Right Ventricular Cardiomyopathy [Elektronische Daten] [Ilaria Rigato, Domenico Corrado, Cristina Basso, Alessandro Zorzi, Kalliopi Pilichou, Barbara Bauce, Gaetano Thiene] Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a genetically determined rare cardiomyopathy (1 in 5000 to 1 in 2000 in the general population), which can lead to ventricular arrhythmias and sudden death (SD). The classic form of the disease has a predilection for the right ventricle (RV), but recognition of left-dominant and biventricular variants led to the broader term "Arrhythmogenic Cardiomyopathy”. The disease affects men more frequently than women and becomes clinically overt usually from the second to the fourth decade of life. Treatment consists of restriction of physical exercise, antiarrhythmic drugs, catheter ablation and ICD implantation. These treatments have the potential to change the natural history of the disease by protecting against SD and offering a good-quality and nearly normal life-expectancy. Antiarrhythmic drugs play an important role in terms of reduction of both the number and the complexity of arrhythmias, but they do not reduce the risk of SD. The results of catheter ablation are poor because of the high rate of VT recurrence. ICD should be reserved to selected patients after an accurate risk stratification. The clinical challenge is to improve risk stratification for better identification of those patients who most benefit from the above therapies. Unfortunately, a curative therapy is not yet available. Springer Science+Business Media New York, 2015 Cardiomyopathy nationallicence Arrhythmias nationallicence Sudden death nationallicence Implantable cardioverter defibrillator nationallicence Drug therapy nationallicence Rigato Ilaria Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy aut Corrado Domenico Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy aut Basso Cristina Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy aut Zorzi Alessandro Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy aut Pilichou Kalliopi Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy aut Bauce Barbara Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy aut Thiene Gaetano Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy aut Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/2(2015-04-01), 171-177 0920-3206 29:2<171 2015 29 10557 https://doi.org/10.1007/s10557-015-6583-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10557-015-6583-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rigato Ilaria Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Corrado Domenico Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Basso Cristina Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Zorzi Alessandro Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Pilichou Kalliopi Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Bauce Barbara Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy aut NATIONALLICENCE 700 1- Thiene Gaetano Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/2(2015-04-01), 171-177 0920-3206 29:2<171 2015 29 10557