caa a22 4500 606158839 CHVBK 20210128100621.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10557-014-6569-y doi (NATIONALLICENCE)springer-10.1007/s10557-014-6569-y Chronic Obstructive Pulmonary Disease and Ischemic Heart Disease Comorbidity: Overview of Mechanisms and Clinical Management [Elektronische Daten] [Gianluca Campo, Rita Pavasini, Michele Malagù, Susanna Mascetti, Simone Biscaglia, Claudio Ceconi, Alberto Papi, Marco Contoli] In the last few years, many studies focused their attention on the relationship between chronic obstructive pulmonary disease (COPD) and ischemic heart disease (IHD), showing that these diseases are mutually influenced. Many different biological processes such as hypoxia, systemic inflammation, endothelial dysfunction, heightened platelet reactivity, arterial stiffness and right ventricle modification interact in the development of the COPD-IHD comorbidity, which therefore deserves special attention in early diagnosis and treatment. Patients with COPD-IHD comorbidity have a worst outcome, when compared to patients with only COPD or only IHD. These patients showed a significant increase on risk of adverse events and of hospital readmissions for recurrent myocardial infarction, heart failure, coronary revascularization, and acute exacerbation of COPD. Taken together, these complications determine a significant increase in mortality. In most cases death occurs for cardiovascular cause, soon after an acute exacerbation of COPD or a cardiovascular adverse event. Recent data regarding incidence, mechanisms and prognosis of this comorbidity, along with the development of new drugs and interventional approaches may improve the management and long-term outcome of COPD-IHD patients. The aim of this review is to describe the current knowledge on COPD-IHD comorbidity. Particularly, we focused our attention on underlying pathological mechanisms and on all treatment and strategies that may improve and optimize the clinical management of COPD-IHD patients. Springer Science+Business Media New York, 2015 Chronic obstructive pulmonary disease nationallicence Ischemic heart disease nationallicence Myocardial infarction nationallicence Comorbidity nationallicence Mortality nationallicence Campo Gianluca Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna di Ferrara, Cona, FE, Italy aut Pavasini Rita Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna di Ferrara, Cona, FE, Italy aut Malagù Michele Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna di Ferrara, Cona, FE, Italy aut Mascetti Susanna Research Centre on Asthma and COPD, Section of Internal and Cardio-Respiratory Medicine, University of Ferrara, Ferrara, Italy aut Biscaglia Simone Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna di Ferrara, Cona, FE, Italy aut Ceconi Claudio Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna di Ferrara, Cona, FE, Italy aut Papi Alberto Research Centre on Asthma and COPD, Section of Internal and Cardio-Respiratory Medicine, University of Ferrara, Ferrara, Italy aut Contoli Marco Research Centre on Asthma and COPD, Section of Internal and Cardio-Respiratory Medicine, University of Ferrara, Ferrara, Italy aut Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/2(2015-04-01), 147-157 0920-3206 29:2<147 2015 29 10557 https://doi.org/10.1007/s10557-014-6569-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10557-014-6569-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Campo Gianluca Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna di Ferrara, Cona, FE, Italy aut NATIONALLICENCE 700 1- Pavasini Rita Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna di Ferrara, Cona, FE, Italy aut NATIONALLICENCE 700 1- Malagù Michele Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna di Ferrara, Cona, FE, Italy aut NATIONALLICENCE 700 1- Mascetti Susanna Research Centre on Asthma and COPD, Section of Internal and Cardio-Respiratory Medicine, University of Ferrara, Ferrara, Italy aut NATIONALLICENCE 700 1- Biscaglia Simone Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna di Ferrara, Cona, FE, Italy aut NATIONALLICENCE 700 1- Ceconi Claudio Cardiovascular Institute, Azienda Ospedaliera Universitaria S.Anna di Ferrara, Cona, FE, Italy aut NATIONALLICENCE 700 1- Papi Alberto Research Centre on Asthma and COPD, Section of Internal and Cardio-Respiratory Medicine, University of Ferrara, Ferrara, Italy aut NATIONALLICENCE 700 1- Contoli Marco Research Centre on Asthma and COPD, Section of Internal and Cardio-Respiratory Medicine, University of Ferrara, Ferrara, Italy aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/2(2015-04-01), 147-157 0920-3206 29:2<147 2015 29 10557