caa a22 4500 606158855 CHVBK 20210128100621.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s10557-015-6585-6 doi (NATIONALLICENCE)springer-10.1007/s10557-015-6585-6 Correlation Between SNPs in Candidate Genes and VerifyNow-Detected Platelet Responsiveness to Aspirin and Clopidogrel Treatment [Elektronische Daten] [Hanbin Cui, Shaoyi Lin, Xiaomin Chen, Wenhui Gao, Xiaojing Li, Honglin Zhou, Weiping Du, Shenghuang Wang, Ruochi Zhao] Purpose: Patients with high on-treatment platelet reactivity (HPR) against aspirin or clopidogrel are at increased risk for adverse cardiovascular events. In this study, we explored the predictive value of common SNPs for the on-treatment platelet reactivity (OPR) against aspirin and clopidogrel assessed by VerifyNow assays. Methods: This study recruited 286 Han Chinese individuals undergoing antiplatelet treatment, including 159 cases with aspirin only (100mg/day) and 127 cases with dual therapy (aspirin 100mg/day plus clopidogrel 75mg/day) for at least 2weeks. The OPR against aspirin and clopidogrel were assessed by VerifyNow Aspirin (ARU) and P2Y12 assays (PRU), respectively. Genotyping for the selected 25 SNPs within 11 genes and 2 GWAS loci was carried out by ABI multiplex SNaPshot method. Results: The results indicated that rs4244285 (CYP2C19) and rs342293 (7q22.3) were significantly associated with PRU value (both P < 0.01). As for the OPR to aspirin, a weak statistical significance was observed in rs5445 (GNB3) (P = 0.049) and rs5758 (TBXA2R) (P = 0.045). After adjusting for the covariates including gender, age and smoking, carriers of allele A of rs4244285 remained as a strong predictor for HPR against clopidogrel. Conclusion: The current study suggests that common SNPs may predict OPR against clopidogrel as assessed by VerifyNow P2Y12, but are less likely to respond against aspirin as assessed by VerifyNow Aspirin. Springer Science+Business Media New York, 2015 SNP nationallicence High on-treatment platelet reactivity nationallicence Aspirin nationallicence Clopidogrel nationallicence VerifyNow assay nationallicence Cui Hanbin Cardiology Center, Ningbo First Hospital, Ningbo University, 315010, Ningbo, People's Republic of China aut Lin Shaoyi Cardiology Center, Ningbo First Hospital, Ningbo University, 315010, Ningbo, People's Republic of China aut Chen Xiaomin Cardiology Center, Ningbo First Hospital, Ningbo University, 315010, Ningbo, People's Republic of China aut Gao Wenhui Cardiology Center, Ningbo First Hospital, Ningbo University, 315010, Ningbo, People's Republic of China aut Li Xiaojing Cardiology Center, Ningbo First Hospital, Ningbo University, 315010, Ningbo, People's Republic of China aut Zhou Honglin Cardiology Center, Ningbo First Hospital, Ningbo University, 315010, Ningbo, People's Republic of China aut Du Weiping Cardiology Center, Ningbo First Hospital, Ningbo University, 315010, Ningbo, People's Republic of China aut Wang Shenghuang Cardiology Center, Ningbo First Hospital, Ningbo University, 315010, Ningbo, People's Republic of China aut Zhao Ruochi Cardiology Center, Ningbo First Hospital, Ningbo University, 315010, Ningbo, People's Republic of China aut Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/2(2015-04-01), 137-146 0920-3206 29:2<137 2015 29 10557 https://doi.org/10.1007/s10557-015-6585-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10557-015-6585-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cui Hanbin Cardiology Center, Ningbo First Hospital, Ningbo University, 315010, Ningbo, People's Republic of China aut NATIONALLICENCE 700 1- Lin Shaoyi Cardiology Center, Ningbo First Hospital, Ningbo University, 315010, Ningbo, People's Republic of China aut NATIONALLICENCE 700 1- Chen Xiaomin Cardiology Center, Ningbo First Hospital, Ningbo University, 315010, Ningbo, People's Republic of China aut NATIONALLICENCE 700 1- Gao Wenhui Cardiology Center, Ningbo First Hospital, Ningbo University, 315010, Ningbo, People's Republic of China aut NATIONALLICENCE 700 1- Li Xiaojing Cardiology Center, Ningbo First Hospital, Ningbo University, 315010, Ningbo, People's Republic of China aut NATIONALLICENCE 700 1- Zhou Honglin Cardiology Center, Ningbo First Hospital, Ningbo University, 315010, Ningbo, People's Republic of China aut NATIONALLICENCE 700 1- Du Weiping Cardiology Center, Ningbo First Hospital, Ningbo University, 315010, Ningbo, People's Republic of China aut NATIONALLICENCE 700 1- Wang Shenghuang Cardiology Center, Ningbo First Hospital, Ningbo University, 315010, Ningbo, People's Republic of China aut NATIONALLICENCE 700 1- Zhao Ruochi Cardiology Center, Ningbo First Hospital, Ningbo University, 315010, Ningbo, People's Republic of China aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Springer US; http://www.springer-ny.com 29/2(2015-04-01), 137-146 0920-3206 29:2<137 2015 29 10557