caa a22 4500 606162712 CHVBK 20210128100640.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s11062-015-9492-3 doi (NATIONALLICENCE)springer-10.1007/s11062-015-9492-3 Effects of Bisphenol A and Learning on the Distribution of GABAAα1 Receptors in the Rat Hippocampus and Prefrontal Cortex [Elektronische Daten] [M. Taherianfard, A. Taci] Bisphenol-A (BPA) is a widely distributed chemical having mixed estrogen agonist/antagonist properties. We investigated the effects of introduction of BPA and passive avoidance learning on the distribution of GABAAα1 receptors in the rat prefrontal cortex and hippocampus. BPA (5 and 50 mg/kg·day) was introduced by oral intake for 15 days; learning and memory were tested in a shuttlebox. The distributions of GABAAα1 receptors were investigated by an immunohistochemical procedure. The BPA treatment significantly decreased the density of GABAAα1 receptors in the prefrontal cortex and hippocampus. The distribution of these receptors was significantly denser in BPA-exposed rats subjected to learning than that in rats without learning. Thus, BPA treatment leads to down-regulation of GABAAα1 receptors in the prefrontal cortex and hippocampus. Learning a passive avoidance reaction provides up-regulation of such receptors in these brain structures. Springer Science+Business Media New York, 2015 bisphenol A (BPA) nationallicence passive avoidance learning nationallicence GABAAα1 receptors nationallicence prefrontal cortex nationallicence hippocampus nationallicence male rats nationallicence Taherianfard M. Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran aut Taci A. Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran aut Neurophysiology Springer US; http://www.springer-ny.com 47/1(2015-02-01), 23-29 0090-2977 47:1<23 2015 47 11062 https://doi.org/10.1007/s11062-015-9492-3 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11062-015-9492-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Taherianfard M. Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran aut NATIONALLICENCE 700 1- Taci A. Department of Physiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran aut NATIONALLICENCE 773 0- Neurophysiology Springer US; http://www.springer-ny.com 47/1(2015-02-01), 23-29 0090-2977 47:1<23 2015 47 11062