caa a22 4500 606162763 CHVBK 20210128100640.0 cr unu---uuuuu 210128e20150201xx s 000 0 eng 10.1007/s11062-015-9501-6 doi (NATIONALLICENCE)springer-10.1007/s11062-015-9501-6 Effects of Neural Crest-Derived Multipotent Stem Cells on Regeneration of an Injured Peripheral Nerve in Mice [Elektronische Daten] [R. Vasyliev, A. Rodnichenko, S. Shamalo, A. Demidchouk, I. Labunets, Yu. Chaikovskii, G. Butenko] We studied the effect of transplantation of neural crest-derived multipotent stem cells (NC-MSCs) obtained from vibrissa germs on regeneration of the injured (transected) sciatic nerve in adult mice (strain FVB). After transplantation of the cells into the injured region, regeneration of the severed nerve was intensified, as compared with that in mice with no implantation. The intensity of vascularization and renewal of the endoneurium also increased. The density of nerve fibers in the distal part of the injured nerve in mice after transplantation of NC-MSCs (10522.8 ± 1044.0 mm-2) was significantly higher than that in mice with nerve injury but without transplantation (8409.5 ± 739.5 mm-2). Possible mechanisms of acceleration of regeneration of the injured peripheral nerve under conditions of transplantation of stem cells are discussed. Springer Science+Business Media New York, 2015 stem cells nationallicence peripheral nerve nationallicence transplantation nationallicence regeneration nationallicence Vasyliev R. State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut Rodnichenko A. State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut Shamalo S. Bogomolets National Medical University, Ministry of Public Health of Ukraine, Kyiv, Ukraine aut Demidchouk A. State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut Labunets I. State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut Chaikovskii Yu Bogomolets National Medical University, Ministry of Public Health of Ukraine, Kyiv, Ukraine aut Butenko G. State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut Neurophysiology Springer US; http://www.springer-ny.com 47/1(2015-02-01), 80-83 0090-2977 47:1<80 2015 47 11062 https://doi.org/10.1007/s11062-015-9501-6 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11062-015-9501-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vasyliev R. State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Rodnichenko A. State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Shamalo S. Bogomolets National Medical University, Ministry of Public Health of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Demidchouk A. State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Labunets I. State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Chaikovskii Yu Bogomolets National Medical University, Ministry of Public Health of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Butenko G. State Institute of Genetic and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Springer US; http://www.springer-ny.com 47/1(2015-02-01), 80-83 0090-2977 47:1<80 2015 47 11062