caa a22 4500 60616281X CHVBK 20210128100640.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s11062-015-9523-0 doi (NATIONALLICENCE)springer-10.1007/s11062-015-9523-0 Dopamine Responsiveness in the Nucl. Accumbens Shell and Parameters of the Heroin-Influenced Conditioned Place Preference in Rats [Elektronische Daten] [Ch. Wang, H. Chen, X. Wang, R. Zhang, W. Hao] Previous evidence demonstrated that drug-induced extracellular dopamine (DA) concentrations in the nucl. accumbens shell (AcbSh) might underlie different vulnerabilities to heroin addiction in inbred mice strains. We investigated a potential role of the responsiveness of the DA system in the AcbSh with respect to the vulnerability to heroin-influenced conditioned place preference (CPP) in rats. Animals were randomly assigned to the heroin and saline (control) groups. Heroin-group rats were then reclassified into two groups according to the degree of heroin-induced CPP, high preference (HP) and low-preference (LP) ones. The levels of extracellular DA and dihydroxyphenyl acetic acid (DOPAC) were estimated dynamically by in vivo microdialysis. Compared with the saline group, extracellular DA and DOPAC concentrations in the heroin-treated groups were significantly higher 30 min after the last injection, but the DA level decreased sharply in these groups on days 1 and 3 and became lower than that of the saline group. Compared with LP-group rats, HP-rats displayed a higher heroin-induced increase in the DA concentration 30 min after the last heroin injection and higher DOPAC and DOPAC/DA ratios 14 days after such injection. These results suggest that differences in the DA system responsiveness in the AcbSh may determine individual differences in vulnerability to heroin addiction. Springer Science+Business Media New York, 2015 nucl. accumbens shell nationallicence heroin addiction nationallicence vulnerability nationallicence dopamine nationallicence conditioned place preference (CPP) nationallicence Wang Ch Second Affiliated Hospital, Xinxiang Medical University, Xinxiang, China aut Chen H. Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China aut Wang X. Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China aut Zhang R. Second Affiliated Hospital, Xinxiang Medical University, Xinxiang, China aut Hao W. Second Affiliated Hospital, Xinxiang Medical University, Xinxiang, China aut Neurophysiology Springer US; http://www.springer-ny.com 47/3(2015-06-01), 212-217 0090-2977 47:3<212 2015 47 11062 https://doi.org/10.1007/s11062-015-9523-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11062-015-9523-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Ch Second Affiliated Hospital, Xinxiang Medical University, Xinxiang, China aut NATIONALLICENCE 700 1- Chen H. Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China aut NATIONALLICENCE 700 1- Wang X. Mental Health Institute, Second Xiangya Hospital, Central South University, Changsha, China aut NATIONALLICENCE 700 1- Zhang R. Second Affiliated Hospital, Xinxiang Medical University, Xinxiang, China aut NATIONALLICENCE 700 1- Hao W. Second Affiliated Hospital, Xinxiang Medical University, Xinxiang, China aut NATIONALLICENCE 773 0- Neurophysiology Springer US; http://www.springer-ny.com 47/3(2015-06-01), 212-217 0090-2977 47:3<212 2015 47 11062