caa a22 4500 606162828 CHVBK 20210128100641.0 cr unu---uuuuu 210128e20150601xx s 000 0 eng 10.1007/s11062-015-9527-9 doi (NATIONALLICENCE)springer-10.1007/s11062-015-9527-9 Role of the Serotonergic System in Suppression of Visceral Pain Induced in Mice by Preliminary Microwave Irradiation of an Acupuncture Point [Elektronische Daten] [Ye. Gura, Ye. Bagatskaya] In experiments on male albino mice, we examined the role of the serotonergic cerebral system in analgesia induced by microwave irradiation of the acupuncture point (AP) E-36. Two modes of irradiation were used: broadband (30-300 GHz) radiation with low-frequency (0.1-100 Hz) amplitude modulation and fixed-frequency (61 ± 4 GHz) radiation. Irradiation of the AP preceded induction of visceral pain by i.p. injections of acetic acid. A blocker of serotonin (ST) synthesis, DL para-chlorophenylalanine (PCPA, 300 mg/kg), introduced 72 h before injection of acetic acid, provided significant prolongation of manifestations of the pain behavioral reaction (PBR) by 41.6 and 66.7%, respectively, as compared with the duration of this reaction in mice subjected to irradiation of the AP in the above modes but with no PCPA injection (P < 0.05 in both cases). Intensification of the PBR against the background of blockade of ST synthesis shows that the respective cerebral system is significantly involved in analgesia induced by preliminary (preceding the induction of the pain syndrome) microwave irradiation of the AP E-36. Springer Science+Business Media New York, 2015 acupuncture point (AP) E-36 nationallicence visceral pain nationallicence preliminary microwave AP irradiation nationallicence cerebral serotonergic system nationallicence Gura Ye Bogomolets Institute of Physiology of the NAS of Ukraine, Kyiv, Ukraine aut Bagatskaya Ye Bogomolets Institute of Physiology of the NAS of Ukraine, Kyiv, Ukraine aut Neurophysiology Springer US; http://www.springer-ny.com 47/3(2015-06-01), 238-243 0090-2977 47:3<238 2015 47 11062 https://doi.org/10.1007/s11062-015-9527-9 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11062-015-9527-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gura Ye Bogomolets Institute of Physiology of the NAS of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Bagatskaya Ye Bogomolets Institute of Physiology of the NAS of Ukraine, Kyiv, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Springer US; http://www.springer-ny.com 47/3(2015-06-01), 238-243 0090-2977 47:3<238 2015 47 11062