caa a22 4500 606162941 CHVBK 20210128100641.0 cr unu---uuuuu 210128e20150801xx s 000 0 eng 10.1007/s11062-015-9542-x doi (NATIONALLICENCE)springer-10.1007/s11062-015-9542-x Neurophysiological and Neurochemical Mechanisms Underlying Depression Disorders and Search for New Directions of Treatment [Elektronische Daten] [I. Abramets, D. Evdokimov, Yu. Sidorova] Depression is a severe mental pathological condition that poses a threat to life; each year, it afflicts a growing number of humans. Depression increases the risk of suicide and promotes the development of cardiovascular, metabolic, and other diseases. At present, therapy of the depressive syndrome is still insufficiently effective. Difficulties in therapeutic treatment of this syndrome are, to a considerable extent, due to the fact that it should be considered a continuum of subsyndromes based on different neurophysiological and neurochemical mechanisms. In this review, we analyze and discuss functional changes in the three main limbic structures (medial prefrontal cortex, nucl. accumbens, and basolateral nucleus of the amygdala) related to behavioral depression in animals induced by repeated introduction of glucocorticoids (GCs), action of chronic inflammation/pain, or the abstinence syndrome after withdrawal of pharmacological agents that caused drug addiction. Based on the revealed functional disorders in neuronal ensembles of the above-mentioned limbic structures, some possible pathways necessary for optimization of therapy of different variants of the depressive syndrome are proposed. Springer Science+Business Media New York, 2015 depressive syndrome nationallicence medial prefrontal cortex nationallicence nucl. accumbens nationallicence amygdala nationallicence synaptic transmission nationallicence synaptic plasticity nationallicence functional disorders nationallicence pharmacological correction nationallicence Abramets I. Donetsk National Medical University, Ministry of Public Health of Ukraine, Donetsk, Ukraine aut Evdokimov D. Donetsk National Medical University, Ministry of Public Health of Ukraine, Donetsk, Ukraine aut Sidorova Yu Donetsk National Medical University, Ministry of Public Health of Ukraine, Donetsk, Ukraine aut Neurophysiology Springer US; http://www.springer-ny.com 47/4(2015-08-01), 348-361 0090-2977 47:4<348 2015 47 11062 https://doi.org/10.1007/s11062-015-9542-x text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11062-015-9542-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abramets I. Donetsk National Medical University, Ministry of Public Health of Ukraine, Donetsk, Ukraine aut NATIONALLICENCE 700 1- Evdokimov D. Donetsk National Medical University, Ministry of Public Health of Ukraine, Donetsk, Ukraine aut NATIONALLICENCE 700 1- Sidorova Yu Donetsk National Medical University, Ministry of Public Health of Ukraine, Donetsk, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Springer US; http://www.springer-ny.com 47/4(2015-08-01), 348-361 0090-2977 47:4<348 2015 47 11062