caa a22 4500 606163069 CHVBK 20210128100642.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s11062-015-9514-1 doi (NATIONALLICENCE)springer-10.1007/s11062-015-9514-1 Aging-Related Peculiarities of the Distribution of Myelin Basic Protein in Cerebral Structures of Gerbils [Elektronische Daten] [Yu. Koval'chuk, A. Zhdankin, G. Ushakova] Using an indirect immuno-enzyme technique, we measured the contents of myelin basic protein (MBP) in different cerebral structures of young adult and old (6- and 24-month-old, respectively) mongolian gerbils. The mean MBP content in the cerebellum of old gerbils was about 47% of the corresponding value in younger individuals (1.04 ± 0.10 and 2.20 ± 0.50 μg per 100 mg tissue, respectively). At the same time, the mean MBP contents in the thalamus and hippocampus of old gerbils demonstrated no decrease and even somewhat exceeded the corresponding values in young animals (the differences were, however, insignificant). Thus, aging-related changes in the MBP content in different brain structures of gerbils demonstrate clearly expressed specificities; there are reasons to believe that age-related processes of demyelination develop, first of all, in the cerebellum. Springer Science+Business Media New York, 2015 myelin basic protein (MBP) nationallicence mongolian gerbils nationallicence cerebral structures nationallicence aging nationallicence Koval'chuk Yu Honchar Dnipropetrivs'k National University, Dnipropetrivs'k, Ukraine aut Zhdankin A. Honchar Dnipropetrivs'k National University, Dnipropetrivs'k, Ukraine aut Ushakova G. Honchar Dnipropetrivs'k National University, Dnipropetrivs'k, Ukraine aut Neurophysiology Springer US; http://www.springer-ny.com 47/2(2015-04-01), 165-167 0090-2977 47:2<165 2015 47 11062 https://doi.org/10.1007/s11062-015-9514-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11062-015-9514-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koval'chuk Yu Honchar Dnipropetrivs'k National University, Dnipropetrivs'k, Ukraine aut NATIONALLICENCE 700 1- Zhdankin A. Honchar Dnipropetrivs'k National University, Dnipropetrivs'k, Ukraine aut NATIONALLICENCE 700 1- Ushakova G. Honchar Dnipropetrivs'k National University, Dnipropetrivs'k, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Springer US; http://www.springer-ny.com 47/2(2015-04-01), 165-167 0090-2977 47:2<165 2015 47 11062