caa a22 4500 606163077 CHVBK 20210128100642.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s11062-015-9515-0 doi (NATIONALLICENCE)springer-10.1007/s11062-015-9515-0 Effects of Modifications of the Functional State of the Central Cholinergic System on Neurological Deficiency Related to Experimental Traumatic Brain Injury [Elektronische Daten] [S. Zyablitsev, S. Khudoley, Yu. Sudilovskaya, Yu. Strel'chenko] Using a 100-point Todd scale, we examined the level of neurological deficiency in male albino rats subjected to dosed experimental traumatic brain injury (TBI). In one of the three experimental groups with TBI, animals were not subjected to additional influences; in another group, the central cholinergic system (CChS) was activated by introduction of a central-action cholinomimetic, choline alfoscerate (Gliatilin); in the third group, the activity of the above system was suppressed by a cholinoblocker, biperiden (Akineton). In rats with TBI, the level of neurological deficiency progressively increased; in this group, the estimates at 3 and 72 h after TBI induction corresponded to 474 and 950% of the respective values in intact animals. Blocking of the cholinergic system additionally aggravated manifestations of neurological deficiency, especially within earlier time intervals after TBI (3 and 24 h). Pharmacological activation of the CChS significantly smoothed manifestations of neurological disorders (several times, as compared with those in the TBI group with no additional influences). Springer Science+Business Media New York, 2015 central cholinergic system nationallicence traumatic brain injury (craniocerebral trauma) nationallicence neurological deficiency nationallicence Zyablitsev S. Donetsk National Medical University, Ministry of Public Health, Donetsk, Ukraine aut Khudoley S. Donetsk National Medical University, Ministry of Public Health, Donetsk, Ukraine aut Sudilovskaya Yu Donetsk National Medical University, Ministry of Public Health, Donetsk, Ukraine aut Strel'chenko Yu Donetsk National Medical University, Ministry of Public Health, Donetsk, Ukraine aut Neurophysiology Springer US; http://www.springer-ny.com 47/2(2015-04-01), 168-170 0090-2977 47:2<168 2015 47 11062 https://doi.org/10.1007/s11062-015-9515-0 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11062-015-9515-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zyablitsev S. Donetsk National Medical University, Ministry of Public Health, Donetsk, Ukraine aut NATIONALLICENCE 700 1- Khudoley S. Donetsk National Medical University, Ministry of Public Health, Donetsk, Ukraine aut NATIONALLICENCE 700 1- Sudilovskaya Yu Donetsk National Medical University, Ministry of Public Health, Donetsk, Ukraine aut NATIONALLICENCE 700 1- Strel'chenko Yu Donetsk National Medical University, Ministry of Public Health, Donetsk, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Springer US; http://www.springer-ny.com 47/2(2015-04-01), 168-170 0090-2977 47:2<168 2015 47 11062