caa a22 4500 60616314X CHVBK 20210128100642.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s11062-015-9513-2 doi (NATIONALLICENCE)springer-10.1007/s11062-015-9513-2 Two Types of Epileptiform Activity Induced in Rats by Repeated Injections of Subconvulsive Picrotoxin Doses [Elektronische Daten] [O. Denisenko, O. Shandra] Seizure activity in rats was induced by picrotoxin i.p. injected every 30 min for 4 h in subconvulsive doses (0.9 mg/kg in the first and 0.7 mg/kg in subsequent injections). Such picrotoxin-evoked epileptiform activity (EA) could be divided into two types, with the development of exclusively peak-wave (P-W) complexes (68.4%) and with generation of regular cortical peaks and only separate short P-W discharges (31.6%). In animals with EA of the first type, we observed the gradual development of clonic seizures of increasing intensities. In some rats of this group after the final (ninth) injection of picrotoxin, dramatic clonico-tonic seizures were observed. In animals with EA of the second type, the duration of P-W discharges after final injections of picrotoxin was shorter than in rats without generation of cortical peaks; these discharges were accompanied by clonic seizures of smaller intensity. Springer Science+Business Media New York, 2015 epileptiform activity nationallicence picrotoxin nationallicence seizures nationallicence peak-wave EEG discharges nationallicence regular cortical peak discharges nationallicence Denisenko O. Odessa National Medical University, Ministry of Public Health of Ukraine, Odessa, Ukraine aut Shandra O. Odessa National Medical University, Ministry of Public Health of Ukraine, Odessa, Ukraine aut Neurophysiology Springer US; http://www.springer-ny.com 47/2(2015-04-01), 160-164 0090-2977 47:2<160 2015 47 11062 https://doi.org/10.1007/s11062-015-9513-2 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11062-015-9513-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Denisenko O. Odessa National Medical University, Ministry of Public Health of Ukraine, Odessa, Ukraine aut NATIONALLICENCE 700 1- Shandra O. Odessa National Medical University, Ministry of Public Health of Ukraine, Odessa, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Springer US; http://www.springer-ny.com 47/2(2015-04-01), 160-164 0090-2977 47:2<160 2015 47 11062