caa a22 4500 606163158 CHVBK 20210128100642.0 cr unu---uuuuu 210128e20150401xx s 000 0 eng 10.1007/s11062-015-9509-y doi (NATIONALLICENCE)springer-10.1007/s11062-015-9509-y Effect of a Hydroalcoholic Extract of Rosa Canina Flowers on Anxiety in Rats [Elektronische Daten] [Z. Nemati, A. Komaki, S. Shahidi, A. Sarihi] We investigated effects of the hydroalcoholic extract of Rosa сanina (dog rose) petals on behavior of rats in the elevated plus-maze (EPM) test; adult male Wistar rats weighing 200-240 g were used. Oral everyday administration of the Rosa extract in three doses (150, 300, and 450 mg/kg) was done for one week. Animal behavior in the EPM was videotaped for 10 min, and conventional indices considered to be related to the anxiety level were scored. Introduction of the Rosa canina extract significantly increased the number of open arm entries in a dose-dependent manner and also increased the time of stay in the open arms at a high dose (450 mg/kg). At the same time, the number of closed arm entries interpreted as a correlate of the locomotion intensity did not differ from the control at all doses. Thus, the Rosa canina extract, when orally administered, demonstrates an anxiolytic profile in rats. Future investigations are essential for better understanding of the anxiolytic properties of the extract and neurobiological mechanisms of its action (probable interactions of the Rose extract active agents with neurotransmitter systems. Springer Science+Business Media New York, 2015 Rosa canina (dog rose) nationallicence anxiety nationallicence elevated plus-maze nationallicence rats nationallicence Nemati Z. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran aut Komaki A. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran aut Shahidi S. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran aut Sarihi A. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran aut Neurophysiology Springer US; http://www.springer-ny.com 47/2(2015-04-01), 133-137 0090-2977 47:2<133 2015 47 11062 https://doi.org/10.1007/s11062-015-9509-y text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s11062-015-9509-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nemati Z. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran aut NATIONALLICENCE 700 1- Komaki A. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran aut NATIONALLICENCE 700 1- Shahidi S. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran aut NATIONALLICENCE 700 1- Sarihi A. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran aut NATIONALLICENCE 773 0- Neurophysiology Springer US; http://www.springer-ny.com 47/2(2015-04-01), 133-137 0090-2977 47:2<133 2015 47 11062