caa a22 4500 606172033 CHVBK 20210128100726.0 cr unu---uuuuu 210128e20151001xx s 000 0 eng 10.1007/s10140-015-1326-5 doi (NATIONALLICENCE)springer-10.1007/s10140-015-1326-5 Implications of radiologic-pathologic correlation for gallbladder disease in children and young adults with sickle cell disease [Elektronische Daten] [Heather Gale, Bindu Setty, Philippa Sprinz, Gheorghe Doros, Don Williams, Trevor Morrison, Tyler Kalajian, Powen Tu, Shankar Mundluru, Manisha Mehta, Ilse Castro-Aragon] The purpose of this study is to describe gallbladderimaging findings in patients with sickle cell disease, andto determine how they correspond with occurrence of complications,need for cholecystectomy, and surgical pathology. This study is IRB approved and HIPAA compliant. Informed consent requirements were waived. We reviewed records of 77 children with sickle cell disease ages 0-18 years at the time of their first gallbladder imaging study. Demographics, hospital courses, and radiologic and pathologic reports were collected. Two pediatric radiologists independently and retrospectively reviewed the imaging studies. Statistical analysis was performed using kappa statistic, chi-squared test, and ANOVA F-test. Continuous variables were described with mean, median, variance, and range. Patients who underwent cholecystectomy (N = 25) were more likely than the patients who did not undergo cholecystectomy (N = 52) to have gallstones or sludge (100 versus 36.5%, p = <0.0001) or other gallbladder or biliary abnormality (70.8 versus 1.9%, p = <0.0001). Patients who did not undergo cholecystectomy more frequently had normal-appearing gallbladders and biliary tracts (63.5 versus 0%, p = <0.0001). Ninety-two percent of patients with cholecystectomy had chronic cholecystitis on pathology, and 96% had a complication, including chronic cholecystitis and sequelae of biliary obstruction. Young patients with sickle cell disease, cholelithiasis, and any other biliary imaging abnormality will almost certainly require cholecystectomy, and many will experience complications. The most common surgical pathologic diagnosis in this group is chronic cholecystitis, which has a variable radiologic appearance. Our findings support recommendations to perform elective cholecystectomy for children and young adults with sickle cell disease and cholelithiasis or gallbladder sludge. American Society of Emergency Radiology, 2015 Sickle cell disease nationallicence Emergency medicine nationallicence Gallbladder and biliary tract abnormalities nationallicence Pediatric surgery nationallicence Ultrasound nationallicence Gale Heather Boston University/Boston Medical Center, 820 Harrison Avenue FGH Building 3rd Floor, 02118, Boston, MA, USA aut Setty Bindu Boston University/Boston Medical Center, 820 Harrison Avenue FGH Building 3rd Floor, 02118, Boston, MA, USA aut Sprinz Philippa Boston University/Boston Medical Center, 850 Harrison Avenue, Yawkey, 4S01, 02118, Boston, MA, USA aut Doros Gheorghe Boston University, 801 Massachusetts Avenue, 02118, Boston, MA, USA aut Williams Don Boston University/Boston Medical Center, 820 Harrison Avenue FGH Building 3rd Floor, 02118, Boston, MA, USA aut Morrison Trevor Boston University/Boston Medical Center, 820 Harrison Avenue FGH Building 3rd Floor, 02118, Boston, MA, USA aut Kalajian Tyler Medical Clinical Sciences/Graduate Medical Studies, Boston University School of Medicine, 820 Harrison Avenue FGH Building 3rd Floor, 02118, Boston, MA, USA aut Tu Powen Beth Israel Deaconess Medical Center, 330 Brookline Avenue, 02215, Boston, MA, USA aut Mundluru Shankar Boston University School of Medicine, 820 Harrison Avenue FGH Building 3rd Floor, 02118, Boston, MA, USA aut Mehta Manisha Beth Israel Deaconess Medical Center, 330 Brookline Avenue, 02215, Boston, MA, USA aut Castro-Aragon Ilse Boston University/Boston Medical Center, 820 Harrison Avenue FGH Building 3rd Floor, 02118, Boston, MA, USA aut Emergency Radiology Springer Berlin Heidelberg 22/5(2015-10-01), 543-551 1070-3004 22:5<543 2015 22 10140 https://doi.org/10.1007/s10140-015-1326-5 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 research-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s10140-015-1326-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gale Heather Boston University/Boston Medical Center, 820 Harrison Avenue FGH Building 3rd Floor, 02118, Boston, MA, USA aut NATIONALLICENCE 700 1- Setty Bindu Boston University/Boston Medical Center, 820 Harrison Avenue FGH Building 3rd Floor, 02118, Boston, MA, USA aut NATIONALLICENCE 700 1- Sprinz Philippa Boston University/Boston Medical Center, 850 Harrison Avenue, Yawkey, 4S01, 02118, Boston, MA, USA aut NATIONALLICENCE 700 1- Doros Gheorghe Boston University, 801 Massachusetts Avenue, 02118, Boston, MA, USA aut NATIONALLICENCE 700 1- Williams Don Boston University/Boston Medical Center, 820 Harrison Avenue FGH Building 3rd Floor, 02118, Boston, MA, USA aut NATIONALLICENCE 700 1- Morrison Trevor Boston University/Boston Medical Center, 820 Harrison Avenue FGH Building 3rd Floor, 02118, Boston, MA, USA aut NATIONALLICENCE 700 1- Kalajian Tyler Medical Clinical Sciences/Graduate Medical Studies, Boston University School of Medicine, 820 Harrison Avenue FGH Building 3rd Floor, 02118, Boston, MA, USA aut NATIONALLICENCE 700 1- Tu Powen Beth Israel Deaconess Medical Center, 330 Brookline Avenue, 02215, Boston, MA, USA aut NATIONALLICENCE 700 1- Mundluru Shankar Boston University School of Medicine, 820 Harrison Avenue FGH Building 3rd Floor, 02118, Boston, MA, USA aut NATIONALLICENCE 700 1- Mehta Manisha Beth Israel Deaconess Medical Center, 330 Brookline Avenue, 02215, Boston, MA, USA aut NATIONALLICENCE 700 1- Castro-Aragon Ilse Boston University/Boston Medical Center, 820 Harrison Avenue FGH Building 3rd Floor, 02118, Boston, MA, USA aut NATIONALLICENCE 773 0- Emergency Radiology Springer Berlin Heidelberg 22/5(2015-10-01), 543-551 1070-3004 22:5<543 2015 22 10140