caa a22 4500 606174567 CHVBK 20210128100738.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00018-014-1713-1 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1713-1 A potential pathophysiological role for galectins and the renin-angiotensin system in preeclampsia [Elektronische Daten] [Sandra Blois, Ralf Dechend, Gabriela Barrientos, Anne Staff] This review discusses a potential role of galectins and the renin-angiotensin system (RAS) in the pathophysiology of preeclampsia (PE). Preeclampsia affects between 3 and 5% of all pregnancies and is a heterogeneous disease, which may be caused by multiple factors. The only cure is the delivery of the placenta, which may result in a premature delivery and baby. Probably due to its heterogeneity, PE studies in human have hitherto only led to the identification of a limited number of factors involved in the pathogenesis of the disease. Animal models, particularly in mice and rats, have been used to gain further insight into the molecular pathology behind PE. In this review, we discuss the picture emerging from human and animal studies pointing to galectins and the RAS being associated with the PE syndrome and affecting a broad range of cellular signaling components. Moreover, we review the epidemiological evidence for PE increasing the risk of future cardiovascular disease later in life. Springer Basel, 2014 Preeclampsia nationallicence Galectins nationallicence Acute atherosis nationallicence Renin-angiotensin system nationallicence Blois Sandra Charité Center 12 Internal Medicine and Dermatology, Reproductive Medicine Research Group, Universitätsmedizin Berlin, Berlin, Germany aut Dechend Ralf Experimental and Clinical Research Center (ECRC), Charité-Campus Buch-Max-Delbrück Center for Molecular Medicine and HELIOS Klinikum Berlin-Buch, Berlin, Germany aut Barrientos Gabriela Laboratorio de Medicina Experimental (LME), Hospital Alemán, Buenos Aires, Argentina aut Staff Anne Department of Obstetrics and Department of Gynaecology, Women and Children's Division, Oslo University Hospital, Ullevål and University of Oslo, Oslo, Norway aut Cellular and Molecular Life Sciences Springer Basel 72/1(2015-01-01), 39-50 1420-682X 72:1<39 2015 72 18 https://doi.org/10.1007/s00018-014-1713-1 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1713-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Blois Sandra Charité Center 12 Internal Medicine and Dermatology, Reproductive Medicine Research Group, Universitätsmedizin Berlin, Berlin, Germany aut NATIONALLICENCE 700 1- Dechend Ralf Experimental and Clinical Research Center (ECRC), Charité-Campus Buch-Max-Delbrück Center for Molecular Medicine and HELIOS Klinikum Berlin-Buch, Berlin, Germany aut NATIONALLICENCE 700 1- Barrientos Gabriela Laboratorio de Medicina Experimental (LME), Hospital Alemán, Buenos Aires, Argentina aut NATIONALLICENCE 700 1- Staff Anne Department of Obstetrics and Department of Gynaecology, Women and Children's Division, Oslo University Hospital, Ullevål and University of Oslo, Oslo, Norway aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/1(2015-01-01), 39-50 1420-682X 72:1<39 2015 72 18