caa a22 4500 606174575 CHVBK 20210128100738.0 cr unu---uuuuu 210128e20150101xx s 000 0 eng 10.1007/s00018-014-1727-8 doi (NATIONALLICENCE)springer-10.1007/s00018-014-1727-8 Selective class IIa HDAC inhibitors: myth or reality [Elektronische Daten] [Eros Di Giorgio, Enrico Gagliostro, Claudio Brancolini] The prospect of intervening, through the use of a specific molecule, with a cellular alteration responsible for a disease, is a fundamental ambition of biomedical science. Epigenetic-based therapies appear as a remarkable opportunity to impact on several disorders, including cancer. Many efforts have been made to develop small molecules acting as inhibitors of histone deacetylases (HDACs). These enzymes are key targets to reset altered genetic programs and thus to restore normal cellular activities, including drug responsiveness. Several classes of HDAC inhibitors (HDACis) have been generated, characterized and, in certain cases, approved for the use in clinic. A new frontier is the generation of subtype-specific inhibitors, to increase selectivity and to manage general toxicity. Here we will discuss about a set of molecules, which can interfere with the activity of a specific subclass of HDACs: the class IIa. Springer Basel, 2014 SAHA nationallicence HDAC3 nationallicence HDAC4 nationallicence HDAC5 nationallicence HDAC7 nationallicence HDAC9 nationallicence MEF2 nationallicence p21 nationallicence Therapy nationallicence Apoptosis nationallicence Cell cycle nationallicence Anti-cancer nationallicence Neurodegeneration nationallicence Inflammation nationallicence Di Giorgio Eros Dipartimento di Scienze Mediche e Biologiche, Università degli Studi di Udine, P.le Kolbe, 4, 33100, Udine, Italy aut Gagliostro Enrico Dipartimento di Scienze Mediche e Biologiche, Università degli Studi di Udine, P.le Kolbe, 4, 33100, Udine, Italy aut Brancolini Claudio Dipartimento di Scienze Mediche e Biologiche, Università degli Studi di Udine, P.le Kolbe, 4, 33100, Udine, Italy aut Cellular and Molecular Life Sciences Springer Basel 72/1(2015-01-01), 73-86 1420-682X 72:1<73 2015 72 18 https://doi.org/10.1007/s00018-014-1727-8 text/html Onlinezugriff via DOI BK010053 XK010053 XK010000 Metadata rights reserved Springer special CC-BY-NC licence nationallicence 1 review-article jats NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE 856 40 https://doi.org/10.1007/s00018-014-1727-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Di Giorgio Eros Dipartimento di Scienze Mediche e Biologiche, Università degli Studi di Udine, P.le Kolbe, 4, 33100, Udine, Italy aut NATIONALLICENCE 700 1- Gagliostro Enrico Dipartimento di Scienze Mediche e Biologiche, Università degli Studi di Udine, P.le Kolbe, 4, 33100, Udine, Italy aut NATIONALLICENCE 700 1- Brancolini Claudio Dipartimento di Scienze Mediche e Biologiche, Università degli Studi di Udine, P.le Kolbe, 4, 33100, Udine, Italy aut NATIONALLICENCE 773 0- Cellular and Molecular Life Sciences Springer Basel 72/1(2015-01-01), 73-86 1420-682X 72:1<73 2015 72 18